The Preparation Of Domestic Productive Nanometer Actived Carbon Adsorbing Mitomycin And Targeted Therapy Of Rectal Cancer Lymphatic Metastasis

Metastasis and micrometastasis are the main reasons why rectal cancer can not be cured after radical operation, lymphatic vessel is one of the main ways of rectal cancer diffusion. From the character of rectal cancer metastasis and the results of other solid tumor lymphatic chemotherapy, we think rectal cancer lymphatic chemotherapy maybe also have great significance.Firstly, this study search for optimal matching technology of domestic productive nanometer actived carbon adsorbing mitomycin to made lymphatic targeting preparation through the adsorbing and desorbing experiments.That the drug concentration, pathology changing of tumor cell in lymph nodes of rectal cancer drainage area were investigated among persistent venous or regional extended release chemotherapy and lymphatic chemotherapy using the preparation made. Immune influence of the body were investigated between regional extended release chemotherapy and lymphatic chemotherapy. And accomplished viewing perioperative lymphatic chemotherapy side effect and complication. This is the first time search out optimal matching technology of domestic productive nanometer actived carbon adsorbing mitomycin to made lymphatic targeting preparation. Evidence initially proved that rectal cancer lymphatic chemotherapy can get high drug concentration in the lymphatic syetem of the tumor possible metastasis area, and get antitumor effect from shutdown tumor proliferation, promote tumor apoptosis and adjust proportionality of CD4~+/CD8~+.It based rationale of rectal cancer lymphatic chemotherapy.