| Chronic nasopharyngitis is a diffuse inflammation which occurs in the pharynx mucous membrane, the hypo mucous membrane and the lymph system. Viruses or bacteria infections can cause chronic nasopharyngitis. Pathogen can infect the pharynx directly, and be infected by abutting areas such as the nasal cavities, the paranasal sinus or from decayed teeth. The physical simulating factors include excessive smoking and drinking, high temperature particulate matters, and toxic gas…etc.. Some systemic diseases can cause chronic nasopharyngitis, for example, anemia, constipation, chronic lower respiratoryitis, and meta blood stasis from cardiovascular diseases. In Chinese medicine system, chronic nasopharyngitis is equal to "man-hou-bi" somewhat. The "man-hou-bi" is a disease which the swelling in the pharynx and larynx obstructs swallowing. The chronic syndrome is similar with chronic pharyngitis which is most caused by flaming up of asthenic fire and consumption of kidney Yin. And the chronic syndrome are pink color in the pharynx, dry scorch and uncomfortable---etc. Recently, the causes and treatments of chronic nasopharyngitis become complicative and intangible because of variations in the environment and the life style and diversifications in occupations. Therefore, it is very important for clinic and epidemiology from comprehensive researches for chronic nasopharyngitis.The study included 3 parts which are literature review, epidemiology survey and clinical researches. Literature review focused on realizing pertaining theories that published researches of the chronic pharyngitis diagnosis, treatments and the mechanism using Chinese medicine among biomedical journals from 1994 to 2005. Epidemiology survey was processing thefollow-up epidemiology of chronic pharyngitis, and related factors survey and analysis in Taiwan. Clinical researches sampled 128 cases randomly for the double-blind match model and were quantitatively evaluate the clinical syndrome for chronic pharyngitis. Furthermore, the study evaluated the outcome performance by comparing two Chinese medicine prescriptions of "Experiment prescription" and "Traditional prescription" .I. Literature review:Objectives: The study searched and analyzed these published papers that chronic nasopharyngitis researches in the Chinese traditional medicine remedy chronic nasopharyngitis using herb treatments among biomedical journals from 1994 to 2005. To realize the existent research outcomes of clinical diagnoses and treatments of chronic nasopharyngitis in Chinese medicine, the further studies and clinical diagnoses of chronic nasopharyngitis can refer to these outcomes.Methods: Using CHKD (1994-2005) , and Chinese national knowledge infrastructure (CNKI) (2001-2005) to search published papers published during 1994 to 2005 which were relevant to Chinese herb treatments of chronic nasopharyngitis to analyze the population, treatments and the mechanism. Outcomes: This study found outcomes that compare and analyze literatures of treatments, the diagnosis, and the mechanism of chronic nasopharyngitis using Chinese medicine in a decade. The further studies and clinical treatment and diagnoses of chronic nasopharyngitis can refer to these outcomes.II. Epidemiology SurveyObjectives: Investigated the epidemiology study in chronic nasopharyngitis in Taiwan area. The study discussed and analyzed the related epidemiology factors of chronic nasopharyngitis. Those could be the references for public health, disease control and clinical treatment on chronic nasopharyngitis in the future.1. The study designed a epidemiology questionnaire on chronic nasopharyngitis. 20 questions were in the questionnaire. And the comprehensive questionsinclude sexual, age, education level, carrier, ethnic group, diet experiment (meat diet or vegetarian diet), diet indulgence, life experiment, work environment, allergy history, family history, disease history, chronic nasopharyngitis history and morbidity timing.2. According to the number of population by city in 2000 in Taiwan, the study chose 1/10,000 from them and mailed-out 2,300 questionnaires. Results: 2,300 questionnaires were mailed-out, and 903 questionnaires were received and receiving rate was 39. 21%. The study found that chronic nasopharyngitis had significant relationship with sexual, age, education level, carrier, ethnic group, indulgence, life experiment, work environment, allergy history, family history, disease history, chronic nasopharyngitis history and morbidity timing. But chronic nasopharyngitis did not have significant relationship with diet experiment (meat diet or vegetarian diet), environmental temperature difference, working length and exercise habits. ITJ. Clinical TrialsObjectives: Evaluating the treatment outcomes for experimental prescription of "Experiment prescription" and traditional prescription of "Traditional prescription" . Through comparison knowing these two medicines' treat outcomes for chronic nasopharyngitis. And the study also can give some new perestroika of developing new medicines. Methods:129 chronic nasopharyngitis cases were randomly chose and double-blind method was used. "Experiment prescription" and "Traditional prescription" were taken 180 ml per time, twice a day for 8 weeks. Self-evaluation forms were used before and after the treatment. Subjects criteria:Include criteria: outpatients more than 20 years old and with symptoms of chronic nasopharyngitis. Eliminate criteria: Younger than 20 years old,Could not finish the treatment on the expecting time,Could not fill out the self-evaluation forms detailed before and after the treatment,Taken other medicines during the treatment, and did not limit diet. Outcomes: Both prescriptions "Experiment prescription" and "Traditional prescription" had positive treatment outcome on chronic nasopharyngitis. But experimental prescription "Experiment prescription" had better treatment outcome than traditional prescription "Traditional prescription" from experiments.Conclusions: This study searched, collected and analyzed the literature of chronic nasopharyngitis from the past 10 years. The collections, analyzing and discussions can be the reference on researching or on clinical treatments for chronic nasopharyngitis in the future. The study investigated of related epidemiology factors on chronic nasopharyngitis in Taiwan. The study found that chronic nasopharyngitis had significant relationship with sexual, age, education level, carrier, ethnic group, indulgence, life experiment, work environment, allergy history, family history, disease history, chronic nasopharyngitis history and morbidity timing. But chronic nasopharyngitis did not have significant relationship with diet experiment (meat diet or vegetarian diet), environmental temperature difference, working length and exercise habits. Therefore, the clinical education should suggest public to avoid effecting factors to increase the morbidity of chronic nasopharyngitis, shorten treatment period and also can ease off the clinical symptoms. And the resoults of clinical trials, both prescriptions "Experiment prescription" and "Traditional prescription" had positive treatment outcome on chronic nasopharyngitis. But experimental prescription "Experiment prescription" had better treatment outcome than traditional prescription "Traditional prescription" from experiments. This study can give some new ideas of developing new medicines on chronic nasopharyngitis in the future.
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