Cloning And Characterization Of A Novel Activin Receptor-interacting Protein 3 Gene

Activin, a homodimer or heterodimer of the pA and βB subunits of inhibin, termed Activin A( β A β A) and Activin B( β B β B) and Activin AB( β A β B) respectively, which is a multifunctional growth and differentiation factor that belongs to the transforming growth factor-β (TGF-P) superfamily. Activin can regulate of secretion of follicle-stimulating hormone from pituitary cells, induce of mesoderm in Xenopus laevis embryos, inhibit IL-1β secretion from activated macrophages. Two types of activin receptor have been identified, type Ⅰ and Ⅱ, both of which belong to the family of serine/threonine kinase receptors. Activin binds specifically to the type II receptor, resulting in the activation of the type I receptor. Then, the type I receptor interacts with intracellular signaling molecules, Smads, which regulate transcription of selected genes in a cell-specific manner. As a consequence, factors that control the action of the type II receptor regulate the downstream propagation of activin-induced signaling. Activin receptor-interacting proteins(ActRIPs) are a novel group of signal transduction proteins, which can interact specifically with type II serine/threoine kinase receptors for activin and regulate intracellular signal transduction of activin.On the basis of discovering and cloning the new gene of ActRIP3, we discovered and proved: the character of the interaction between ActRIP3...