Salt-Load Effects On Tissue Pathology And Gene Expression Of SHRsp

Background:Essential hypertension (EH) is a complex and polygene genetic disease. It is well-known that salt play an important role in the pathogenesis of EH and its complications. Salt-sensitive hypertension is an intermeditate phenotype. It is affected by many genetic factors, however the genetic mechanism is still unclear. Many published studies focused on some hypertension associated genes which ignored that multigenes were affected with each other in vivo, so the genetic study of salt-sensitive hypertension should be established on cooperating effects of multifactors in whole body.mRNA differential display is an advanced technique to find different gene expression in various cell or tissue. It is widely used in many research field.SHRsp is an salt sensitive hypertension animal model. There is no genetic mutation among their individuals. It is useful for exploring the association between genetic and enviroment factors in hypertension.Objective:...