Relationship Between Polymorphism Of The Renin-angiotensin-aldosterone System (RAS) Gene And The Response To Angiotensin-converting Enzyme Inhibition In Hypertensive Patients

BACKGROUNDEssential hypertension (EH) is a multifactorial disease affected by both environmental and genetic factors. The response of patients to antihypertensive therapy is variable. A variety of mechanisms determine drug response, such as pharmacokinetic and pharmacodynamic mechanisms. Genetic variation that alters the structure, configuration, or quantity of any of the proteins involved in any of these mechanisms may contribute to interindividual variation in drug response. It has long been suspected that interindividual variation in the efficacy and side-effects of medications may be influenced by genetic factors. Early results support the notion that genetic variation may have pleiotropic effects on numerous biochemical, physiologic, and anatomic measures of...