Effects Of Invigorating The Spleen And Supplying Saccharide On Overtraining Rats Skeletal Muscle GLUT4 And Signal Transductions

Purpose: Different sports events have different mechanism of sports fatigue, traditional Chinese medicine (TCM)and Western medicine(WM) have their own interpretation. WM believes that sports fatigue which big loading endurance exercise caused have something to do with recovery of muscle glycogen; however, TCM considers that "overstraining will cause splenopathy". So different restoring means are used entirely. WM takes supplying saccharide as the principle to quicken the body recovery, and TCM uses the way of invigorating the spleen to improve functions of the spleen and stomach. Two methods have their own of advantages and disadvantages. We combined both methods of invigorating the spleen and supplying saccharide to improve function of the stomach and intestine, increase reserves for energy source substances and enhance capacity for skeletal muscle.In this study we tested hypothesis that long large loading endurance training can cause splenic asthenia from the function of the stomach and intestine, metabolism of saccharide, free radical and signal transduction system in skeletal muscle. The study focused on that invigorating the spleen and supplying saccharide affect P38, ERK in MAPK signal transduction system and PKB in PI3 transduction channels of overtraining mice with splenic asthenia. At the same time it further explored the relationship between invigorating the spleen, supplying saccharide and glycometabolism and metabolism of free radical. It may offer experimental basis for verifying the theories that the spleen is in charge of nourishing the muscles and overstrain cause splenopathy in TCM. It may also develop new ideas for looking for the method of...