Study Of The Development And Relationship Between Mitochondria DNA ATPase6, 8 Gene Mutation And Alcoholic Liver Disease In Rats

Background alcoholic liver disease (ALD) is caused by heavily drink for a long time , it is more often in west countries ; in these years , with the improvement of the standard of living, the incidence of ALD in our country has increased markedly. Excessively drink can not only cause ALD, but also cause some social and psychological disorders .According to the degrees and progress of the disease , ALD is divided into alcoholic minimal lesion, alcoholic fatty liver , alcoholic hepatitis , alcoholic liver fibrosis and alcoholic cirrhosis . Since Addsion and Rokitansky reported the relationship between alcohol and fat metabolism in liver respectively in 1836 and 1849, and brought out the concept of ALD primarily, many scholars had done lots of works to study the pathogenesis of ALD in many aspects. They mainly include chemical reaction and pharmacological mechanism; cytokines, immunology and virology mechanism; genetic mechanism and nutrition mechanism .Excessive drink can cause hyperfunction of the mitochondria respiratory chain and promote the producing of activated oxygen , the activated oxygen then can damage the mitochondria DNA (mtDNA) and cause some changes of the base sequence , the accumulation of abnormal mtDNA then can cause dysfunctions of the respiratory chain, and hence promote the producing of activated oxygen, and at last ,cause gene mutation and cell apoptosis.