Study Of QingXiangSan's Therapeutic Effect And Its Mechanism On Acute Stage Of Inflammatory Bowel Disease Rat Model

BACKGROUNDThe etiology of inflammatory bowel disease is still unknown, but the incidence of this disease is more and more with years gone, and it has become the emphasis disease worthing studying in the diseases of digestive system. Now the current therapeutic regimen is the method of combination of TCM with Clinical medicine. Under the recognition of inflammatory bowel disease from the standpoint of TCM, most of the physician come to a conclusion that this disease must be treated according to the period of acute stage or chronic stage, and the method of heat clear and damp elimination is usually used in the chronic stage, and this belongs to wet and heat syndrome,whereas the method of invigorate the spleen and damp elimination in the acute stage. QingXiangSan is the empirical formula of Professor WuShiJiu who summarized it after having been engaged in the foundation and clinical study for many years, and its function is just the clear and damp elimination and invigorate the spleen. In clinical study, it have been observed to have good effect on colitis including the inflammatory bowel disease that belongs to the syndrome of wet and heat from the opinion of TCM.and the clinical study of QingXiangSan indicates that it can develop the sign of patients with the syndrome of wet and heat and regulate functional disorder of humoral immune function of patient with the syndrome of wet and heat. regarding to the foundation study, it can develop the expression of rat's heat shock protein 70,reduce the gastrointestinal tract inflammatory reaction of rat animal model of wet and heat syndrome, increase the level of serum gastrin,D-...