Study Of Somatostatin Recptor 2 And Nasopharyngeal Carcinoma

Somatostatin is an important pituitary hormone, acting as an inhibitory peptide of various secretory and proliferative respones.It has strong inhibitory effects on gorwth hormone and multiple endocrine and exocrine cell during grounding or irriatated satus. SST in the central nervous system can act as neurotransmitter, adjusting the kinesis and indentification function of cerebrum. And SST can inhibits various the proliferation of normal deviding cells,such as intestinal mucosa, activated lymph cell and inflammatory cell.Coupled with protein G,which is conjucted with multiple signal conduction pathway,somatostatin receptors (SSTR1-5) mediate biologic effects of SST.They express differently in different tissue.It is proved that there are SSTRs, especially SSTR2 in digestive duct and neuroendocrine tumor tissue and cell strain cultured in vitro. And SSTR is proved to be positive in non-endocrine malignant tumor cells.As natural SST effects extensive, and has small selevtivity, a lot of somatostain analogus (SSTA) like octreotide were made,which has long half life and effects relatively unitily and lasting long. Octreotide is used to treat with digestion and endocrine system desease, and also acromegaly,...