| ObjectivesEsophageal carcinoma(EC) is one of the common malignances in the world,and it is a great threaten to human health . The incidence of EC is high in China, which lines the second in the mobidity of digestive gastrointestinal cancer. Rearches aiming at chemoprevention and treatment of EC are being payed more attention. Therefore, it is very important to search for an effective chemoprevention method to decrease the morbidity and mortality of EC.In recent years, being the rate-limiting enzyme that is essential for the conversion of free arachidonic acid into prostaglandins, the role of inducible enzyme cyclooxygenase (COX)-2 in the process of carcinogenesis is being actively studied. It has been reported that COX-2 is overexpressed in many human tumors, thus is considered as a potential target for cancer chemoprevention and treatment. Accumulating epidemiological and experimental investigations have indicated that regular intake of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the risk of gastrointestinal carcinomas such as colorectal carcinoma, EC and gastric carcinoma, in addition, NSAIDs exhibited in vitro growth-inhibitory activity against a variety of human cancer cell lines and induced apoptosis. Whether selective COX-2 inhibitor have antitumor effect on EC, and how they inhibit proliferation in vitro and in vivo has not yet been demonstrated. Recent study suggested that the JAK-STAT (Janus Kinase -Signal transducer and activator of transcription ) signalling pathway may play an important role in the malignant transformation of a number of human malignaces. Signalling is intiated when ligands such as cytokines bind to and activated their cell surface receptors, then subsequently activate the JAKs, which is followed by phosphorylation of STAT.
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