| 1 Reasons and objectives of the researchStroke belongs to cerebral vascular disease in morden medicine. It is one of three death diseases in the world and has the high rates of incidence, death, recrudescence and crippledom. It is a kind of commen and excessive disease which forms menace to the people' s heath. The incidence of stroke increase with the people aging and living level exaltating. More and more attention is payed to study the mechanism and therapeutics of stroke. One of the subject in medical field is improving effect of prevention and cure, lowing the rates of incidence, death, recrudescence and crippledom. In the opinion of the Traditional Chinese Medicine(TCM), the main pathologic factor of cerbral infarction in acute period is the interaction of Feng, Huo, Tan, Yu and Xu, causing the Tan and Yu(blood stasis syndrome) knoted with each other , blocking brain vasculars, then the stroke take places. Among the pathologic factors, tan and Yu pierces through the process of stoke. Although there are a lot of therapeutics , to treat tan and yu is a basic method that cure ischemic stroke.It is hard to cognize the syndromes and pathogenesis of acute of cerbral infarction for its changefully transformation. State Administration of Traditional Chinese Medicine promulgated diagnoses and treatment norm many times so that standardization can direct and promote clinical and scientific research of stroke. However lots of researches illuminated syndrome combination shape of cerbral infarction is complex. For example above 2 symptoms belong to each series of times exist at the same time are particularly obvious in the acute stage. Uncertainty and nonstandard in the type of syndromes seriously block the development of modernized differentiation of syndromes study.This topic embarks from the thinking mode of TCM, it expounds the acutecerbral infarction syndrome in the concept and connotation, the pathology and physiology, use CGRP and ET to reseach the change of ACI syndrome summarize its clinical application and its regularity, discuss its path-physiology foundation, compare effect and the mechanism of action with the commonly used the principles of TCM, service for clinical applying the theory of ACI, while choose biological collection related to blood stasis syndrome to survey the change of CGRP and ET in the whole acute stage, find the relationship between CGRP/ET and ACI, try hard to find means to prevention and cure ACI. 2 clinical research methods 2. 1 ACI syndrome research methodsBy analyzing the correlation literature and the clinical material, Combining the related explanation in the present teaching material, we try to elucidate and deduce comprehensively the concept and physiological connotation of ACI. We summarize clinical experience, rather entirely take cognizance of cerbral infarction commonness pathogenesis, syndromes characteristic of AC! syndrome, through having systems reviewed the factors and pathogenesis discussion of ACI in modern times. Thus foundation is provided for preparatory work in the earlier period for the further experimental study 2.2 The clinical researchCases was gathered from Guang Dong province TCM Hospital, all according to the standard of including and excluding norm strictly. Investigated objects are separated in four time points, such as 3rd day, 7th day, 14th day and 28st day. Doctors of TCM attending physician or attending physician upwards research personnel collects the information of syndrome on the basis of inspection, listening and smelling, asking, pulse-taking. They accomplish differentitation of syndromes separately with independence according to the standard for cerbral infarction, diagnosis standard of stroke syndrome, traditional Chinese medicine diagnosis standard of stroke, assessing standard of curative effect. And they also fill the case report form table according to the facts.When finished the clinical work, use the information, we got to analyze and summarize the change and distribution of ACI syndrome. 2. 3 The experiment researchCases was gathered from Guang Dong province TCM Hospital, all according to the standard of including and excluding norm strictly. Collected andseparated blood in three time points, such as 3rd day, 7th day, 14th day. thecollection send to handling in time by professional staff, When the collectionwas finished, we got to analyze and summarize the change and relationship ofCGRP and ET in different time points.3 Research results3. 1 clinical research results3. 1. 1 in the early stage of ACI, wind syndromeN heat syndrome, phlegm syndromeand blood stasis syndrome distribute to share great majorityThe proportion of wind syndrome and heat syndrome in the whole acute stage is high, wind syndrome descend quickly later on, and heat syndrome is 51.9 %, with the disease prograss, descend to 26.9% in 14th day. The proportion of qi deficiency syndrome and blood stasis syndrome run to 60%, in whole acute stage, the proportion of phlegm syndrome and blood stasis syndrome was height. The proportion of yin deficiency syndrome was stabilization. The low proportion was yang deficiency syndrome, damp syndrome, qi sluggishness and excess of yang. This occurrence that learn a research with modern Chinese medicine cause of disease to think stroke mainly and wind syndrome, heat syndrome, phlegm syndrome, blood stasis syndrome, qi deficiency syndrome etc. the factor is mutually consistent.3. 1. 2 in whole cerbral infarction, the symptoms to keep on to convert mutually, dynamic state variety.This research tries to match a sufferer's dynamic state observation of bring into the standard afterward a ingredient to wait the conversion regulation. Discover as a result that not meantime inside the single ingredient and five ingredients combines above rarely, 2—4 ingredients combination distribute to share great majority, making progress along with the condition henceforth, the ingredient wait combination is change direction by ingredient (4n 5,6ingredients) to turn in brief, and take 2 and 3 ingredient combinations as gradually many, among the combinations, phlegm+blood stasis+qi deficiency most for see much, blood stasis+qi deficiency is secondly. 3. 1.3 at whole lack an impatient period of the stroke, the wind syndrome variety is the most quick, and wind syndrome with the result that the pathological changes turns quickly relevant," heat syndrome " is being taken bad to have 51.9% in the early period, might be just evil with outbreak to compete with each other hot elephant to then show more in the early period, along with iswin evil back, the heat syndrome was a not notable. The yin deficiency syndrome has been maintain falsely in the stable low level appearance. Afterward remaining if the yang deficiency syndrome, qi sluggishness , damp syndrome, excess of yang etc. have is always very small. Only" phlegm syndrome "/'blood stasis syndrome ", " qi deficiency syndrome " presents high level appearance always, it constitutes to above 60%. 3.2.The clinical studies result3.2.1 CGRP, ET with ACIET in The blood plasma during whole acute stage obviously to compare with matched control, for 3 days,the 7th, 14 days, to compare with matched control, the blood plasma content goes up obviously;(P<0. 01). The CGRP content is lacking an impatient period of the stroke 3rd> 7th days to show to lower, (P<0. 01)to compare with matched control, the 14 days goes up obviously (P<0. 05) .The level of the course of illness early ET is the tallest, and descend gradually with the course of illness, but 14ds still obviously high in matched control (P<0. 01);The CGRP level be taken low in the early period, going up quickly with the course of illness development.3.2.2 CGRP, ET with yin syndromeN yang syndromeyin syndrome and yang syndrome comparison, ET of the yang syndrome, yin syndrome compares a matched control to go up(P<0. 01) obviously the 3rd day, to compare with yang syndrome, the yin syndrome increase high (but P>0. 05), the 7th days, to compare with matched control, yang syndrome, yin syndrome blood plasma ET content goes up (P<0. 05);The CGRP in period of the 3rd days, to compare with matched control, the yang syndrome, yin syndrome lowers ( P<0. 01) To compare with matched control, the 7th, 14 days yin syndrome , yang syndrome both go up (but P>0. 05)3.2.3 The CGRP, ET waits a comparison with each ingredientET of blood stasis syndrome compares other syndromes to go up in period ofthe3rd> 7tfK 14th days (but P>0. 05), CGRP of blood stasis syndrome compares other syndromes to go down in period of the 3rd> 7th> 14th days (but P>0. 05), although P>0. 05, it can tell the tendency: ET in The blood stasis syndrome blood plasma content variety hints the CGRP, ET and blood stasis syndrome ingredient related. Possibility in acute stage, the ET induct cerebral with the meninges blood vessel keep on strong constringency, cause the brain organization to lack blood, anoxia, can aggravate blood stasis syndromeappearance inside the brain, cause the blood stasis syndrome reduce continuously, and the existence of the blood stasis, further hurt brain ego protection and repair function, can't produce enough CGRP. 4. Conclusion4. 1 Rise a disease wind syndrome, qi deficiency syndrome, heat syndrome, phlegm syndrome, blood stasis syndrome most in order to see much, the heat syndrome, phlegm, wind syndrome is a mark for emergency.wind syndrome be suffering a stroke to constitute in the early period higher, descend quickly later on, " phlegm syndrome ", " blood stasis syndrome "," qi deficiency syndrome "," yin deficiency syndrome " constitutes everywhere and more stable, " qi deficiency syndrome "," blood stasis syndrome ", "phlegm" , constitute ratios in the whole impatient period stage case all higher, "the yin deficiency syndrome" is a stability in the lower level. 4. 2 in whole cerbral infarction, the symptoms to keep on to convert mutually, dynamic state variety. Not meantime inside the single ingredient and five ingredients combines above all rarely, the early 2 —4 ingredients combinations distribute to share great majority, henceforth along with the condition make progress, the ingredients combination is change direction by ingredient to turn in brief, and take 2 and 3 ingredients combinations as gradually many, among the combinations, phlegm+blood stasis+qi deficiency most for see much, blood stasis+qi deficiency is secondly. 4.3 CGRP, ET with ACIThis research discovers ET in whole acute stage to has been on a set to go up(P<0. 01) obviously, the elucidation ET and the ACI outbreak is relevant. The content variety elucidation of the CGRP at earlier period of ACI CGRP excessive depletion, and then along with the machine body to the holdout and the protection function of the pathological changes part, synthesize to release a great deal of CGRP, this to ACI occurrence, development with prepare after have certain function, so they seem to be very important in the balance in the body. 4. 4 CGRP, ET with yang syndrome and the yin syndromeET in The blood stasis syndrome content is all high in other sets the 3rd, 7th days;The blood stasis syndrome is high in other sets the 14th day .The blood stasis syndrome blood plasma CGRP content is all low in other sets the 3rd, 7 days;The 14th days is slightly low in other sets, but didn't statisticsto learn meaning.4.5 The CGRP, ET waits a comparison with each ingredientBe lacking the blood stroke impatient period yang syndrome and the yin syndromecomparison, the blood plasma ET the yin syndrome compares a yang syndrome toincrease the 3rd day high, may be yang syndrome is stronger for sense of right,rise but the anti- is evil, past damaged opposite smaller of past.5 Future prospectsIn this research foundation, we should continue thoroughly to discuss the relations and the essence on the change of syndrome of Acute cerbral infarction, unearth the experience of TCM, impel new approaches from the Chinese medicine academic understanding to prevent and cure the cerebral vascular disease which have seriously threatened the human health.
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