The Effect Of Busuishengxue Granule On Related Adhesion Molecule And Cytokine In Chronic Aplastic Anemia Patients

Objective To observe the clinical effect of Busui Shengxue granule (BSSXG) in treating chronic aplastic anemia (CAA) and related factorMethods Sixty cases of CAA were divided into two groups randomly—thirty patients of the treated group were treated with BSSXG and thirty patients of the control group were treated with Zaizhang Shengxue tablet (ZZSXT). We observed the clinical effect of these sixty patients treated with BSSXG and ZZSXT. At the same time, the expression of LFA-1 IL-3R of BMMNC and Fn IL-10 of serum in CAA patients were detected by flow cytometry (FCM) and ELISA respectively before and after treatment by BSSXGResults (l)The total effective rate of BSSXG and ZZSXT were 73.33% and 46.67% , the comparison between the two groups showed significant difference (P<0.05). (2)BSSXG could alleviate CAA patients' anemia symptoms and increase the peripheral blood cells significantly. (3)The expression of CD11a, CD123 were both lower than that in the normal controlled group before treatment, but after treatment they got elevated respectively in different degree. (4)The levels of IL-10, Fn were both higher than that in the normal controlled group before treatment, but after treatment they were regulated respectively in different degree. (5)In BSSXG group, its curative effect was superior in Yang deficiency type to that in Yin deficiency type.Conclusion The Abnomal expression of CDlla CD123 of BMMNC and Fn IL-10 of serum can affect the bone marrow haematopoiesis and is related closely to CAA. BSSXG can improve bone marrow haematopoiesis by regulating the expression after treatment.