Aberration Study Of Familial Myopia

Purpose: To investigate the characteristics of wavefront aberrations in myopic individuals with history of familiar myopia, to explore the possibility that the characteristics of familiar myopia are determined by genetic factors, and then to discuss the role of innate abnormality of wavefront aberrations in the development of familial myopia.Methods: A pilot study by using a psychophysical aberrameter was conducted to insure the accuracy and reliability of this measurement before the following study.In this study, wavefront aberrations were measured in both eyes of 167 subjects, who had been classified into familial high myopia group, simple myopia group, and emmetropia group, respectively.Subjects in simple myopia group were subdivided into three groups based on myopic diopters: mild ( -1D to -3D), moderate ( -3D to -6D), and high (over -6D). Overall wavefront aberration, each order and each term of Zernike aberration in all groups described above were analyzed by SPSS (Statistics Package for Social Science) for Windows statistic software system.25 members from 5 myopic families were subdivided into two groups based on refractive errors: familial high myopia group (over -6D) and familial non-high myopia group (under -6D, including emmetropic and hyperopic individuals).Finally, analysis of covariance was used to compare the contribution of each possible influence factor on wavefront aberration.Results: With same level of refractive error, the mean RMS value of overall wavefront aberrations was greater in the familiarl high myopia group than that in the simple high myopia group. In comparison of each order and...