The Research On The Relation Of The Stability Of Coronary Atherosclerotic Plaque With Hs-CRP And CD105

Background:Acute coronary syndromes are thought to result from atherosclerotic plaque disruption and intramural thrombus formation.Therefore, it is probably important for preventing the acute cardiovascular events with early identification of unstable plaque . Pathologic studies have demonstrated that ruptured plaques have been shown to have several histomorphologic features including a large plaque, a large lipid core, a thin fibrous cap with inflammatory cell infiltration and more neovascularity. Plaque angiogenesis may promote the growth of atheromas, induce intraplaque hemorrhage and plaque disruption, and hereby complication. It is probably significant in preventing the acute cardiovascular events with identifying plaque neovascularization.At present , atherosclerosis is known as an inflammatory- proliferation response of coronary arterial wall to a kind of inflammation injury which involves inflammation, macrophages accumulation, or muscle cells proliferation and migration. Inflammation plays an essential role in the initiation and progression of coronary atherosclerosis, as well as atherosclerotic plaque rupture that culminates in acute coronary syndromes (ACS) .C-reactive protein (CRP) is not only a marker but also a mediator of inflammation and atherogenesis. The activity of inflammation combined with neovascularization may increase unstability of plaque. It is further studyed whether the influence of angiotensin type 1 (AT1) receptor blockers and statins on muscle cells proliferation and migration may diversify stability of plaque.Objective:The purposes of present study are as follows: 1) to investigate the morphological features as well as the vulnerability of atherosclerotic plaques through intravascular ultrasound ( IVUS) in patients with stable angina( SA) and patients with unstable angina(UA); to elucidate the relationship between the circulating level of high-sensitivity C-reactive protein(hs-CRP) or soluble CD105 and the vulnerability of coronary heart disease(CHD), the vulnerability of atherosclerotic plaques and the stenosis...