| Research background: These years, some researches concerned found that the osteoprotegerin/ receptor activitorof NF-kappa B ligand/ receptor activitorof nuclear factor-kappaB system(OPG/RANKL/RANK system) plays a crucial important role in osteoclast of cytodifferentiation and generation. This is a great improvement in the area of bones physiology. Osteoprotegerin(OPG) is a secretde glycoprotein which was found in 1977 which could restrain not only the differentiation of osteoclast, but the activity of mature osteoclast, what's more, induce it's apoptosis. Osteoblast,mesenchymal stem cell and activated T lymphocyte all could express RANKL. When RANKL was combined with RANK, which is in the surface of the osteoclast's original cell or mature osteoblast, it could accelerate the differentiation of osteoclast and the activity of bone's absorbtion. OPG which excreted by Osteoblast and mesenchymal stem cell can competitively bind RANK with RANKL,so OPG can block the bindation between RANK and RANKL. . Many hormones or factors in the body regulate the metabolism of bone by influence the rate of OPG/RANKL in the bone marrow's microenvironment, such as estrogen,TNF-α,TGF-β,1,25(OH)2D3,bone morphogenetic protein-2,PTH,PGE2,glucocorticoid and so on.Furthermore, as the flying development of modern artificial joint technique and some researches concerned, artificial joint replacement has become the most popular and effective method to treat every kinds of joint diseases'pathological changes in the last period. However, the problem that the osteolysis around the artificial joint lead to the asepsis looseness of joint have not been solved appropriately, which become the bottleneck for the further development of this technique and also a hotspot for research. The research in this decade confirm that the asepsis looseness of artificial joint due to the biology reaction which is induced by the particle, generated from long period of artificial body's...
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