Study On Mutation, Expression And Regulation Of DNA Polymerase Beta Gene In Prostate Cancer

Prostate cancer is the second leading cause of cancer deaths among men in Europe. It has exceeded lung cancer and ranked first in USA. Although the morbidity of this disease in our country is much lower than that in the western countries, with the prolongation of life-span, the changes of life style and dietary composition, the morbidity of prostate cancer presents an increasing tendency day by day. The character of this tumor is latency, and therefore it is not easy to diagnose this disease in the early stage. In addition, it is difficult for chemotherapy medicine to come into prostate cancer tissue for treatment. The effectivity of radical prostatectomy for diagnosed case was not satisfatory in that metastatic prostate cancer has been confirmed by then. So far, the precise molecular events leading to prostate carcinogenesis are not well elucidated. Therefore it is of importantly theoretic and practical significance to do some research to reveal the molecular mechanism of prostate cancer, whereby to intervene the occurrence of prostate cancer from the angle of prevention and treatment at the gene level.The study of molecular oncology indicates that the basic reason of the occurrence and development of tumor is due to DNA damage and malfunction of repair. DNA repair gene, oncogene and tumor suppressor gene , which are called the most three important tumor-related genes, exist in human normal cells and restricted each other to maintain the cell growth, differentiation and proliferation . The damage and/or abnormal expression of any kind of gene would result in direct or indirect interferenc in the expression and function presentation of other genes, further to be involved in the malignant transformation of cells. Except for mutation or/and...