Study On DNA Polymerase β, Fas And P53 Gene Mutations And Their Gene Expressions Of MRNA In Human Gliomas

The intracranial tumor is one of the most common diseases in the central nervous system, especially in children frequently seen only next to leukaemia. About 40%~60% of the primary malignant brain tumors are brain gliomas. The classification of gliomas and their malignant degrees are different. At present, the surgical operation, radiation or chemotherapy are chosen for therapy only based on the clinical symptoms, signs and the changes of neuroimage, including MRI, MRA, MRS or PET and so on, so the therapeutic rate of the tumor is very lower. It is well-known that the oncogenes, anti-oncogenes and DNA repair genes are three kinds of tumor genes, present in the human normal cells, and responsible for maintaining normal growth, differentiation and their mutual. When the balance among them once being deregulated the disorder of cell function, DNA damage and gene mutation even would...