Studies Of Oncogene Expression In Acute Leukemia Cells And Its Clinical Significance

Oncogene, tumour suppressor gene p⁵³ and proto-oncogene c-myc, is involved in modulating cell growth and differenti-tation and their alterations are more frequently among human cancers. Many kinds of oncogenes including p⁵³ and c-myc mutations, abnormal expression are associated with pathogenesis and progression of acute leukemia, because infrequent mutations, abnormal expression of oncogenes might be main causes of aberrant proliferation and development of drug resistance of AL cells. In order to study expression of p⁵³, c-myc and its relationship of each other as well as influence on diagnosis, progression and prognosis of AL, 40 patients were analysed in this paper.