Experimental Study Of The Role Of Oxidative Stress In The Pathogenesis Of Diabetic Nephropathy

BackgroundThe original damage caused by diabetes mellitus is due to all kinds of diabetic complications and diabetic nephropathy is one of the most harmful . So it is very important for us to find out the mechanisms of them. The traditional ideas of the mechanisms of diabetic complications include : increased polyol pathway flux, increased intracellular formation of AGEs, activation of protein kinase C, increased flux through the hexosamine pathway. Unifying mechanism, being put forword by professor Michael A. Brownlee, means that the four traditional pathyways are the result of the overproduct of superoxide radical produced in the cell mitochondrial,in other words, the result of oxidative stress.Oxidative stress is considered as the imbalance between the production and clearance of all kinds of radicals.This is usually affected by some factors and results in tissue damage. Some radicals,including O₂^-,H₂O₂,OH^-, are produced during the normal metabolism in different tissues.These radicals are called ROS(reactive oxygen species).On the other hand ,there are some different systems to clear these radicals so as to inhibit the damage caused by them and keep the normal metabolism . These systems are very complicated.The main part of these protective systems are the...