| ObjectiveSarcopenia is a complex syndrome that is characterized by the loss of muscle mass,strength and function.Muscle mass,usually refers to the appendicular skeletal muscle mass,plays an important role in sarcopenia.The decline of muscle mass could be directly affects muscle strength and muscle function.This study is mainly to explore whether there were exist differences in the amount of appendicular skeletal muscle between healthy adults(NGT)and type 2 diabetes mellitus(T2DM),and to further explore the relationship between the amount of appendicular skeletal muscle and gender,age,course of disease,insulin resistance(IR)and diabetic peripheral neuropathy(DPN)in patients with type 2diabetes mellitus(T2DM),in order to support some relevant clinical messages for the occurrence of sarcopenia in patients with type 2 diabetes mellitus.Expecting to attract people,especially the T2 DM in the cognition degree of sp,so as to provide early prevention and intervention of sarcopenia.MethodsWe enrolled a total of 150 subjects in our study,including 50 healthy controls,25 males aged 40.0-80.9 years and 25 females aged 40.3-82.8 years.There were 100 patients with T2 DM,including 55 males aged 40.2-84.3 years and 45 females aged 42.0-88.6 years.The above two groups of people were from December 2017 to November 2018,respectively,who visited the physical examination center of Liaocheng People’s Hospital,heal-thy adults and patients in the Department of endocrinology.All patients with T2 DM met the WHO diagnostic criteria for T2 DM in 1999.The skeletal muscle mass of the two groups was measured by human body composition analyzer(INBODY 770),and the skeletal muscle mass was evaluated by the skeletal muscle index(SMI).To compare the difference of skeletal muscle mass between NGT group and T2 DM group.Then,patients with T2 DM were divided into groups according to gender,age,course of disease,insulin resistance and whether or not they were complicated with peripheral neuropathy,and skeletal muscle mass differences among groups were compared.Results(1)The appendicular skeletal muscle mass of in T2 DM group was significantly lower than that in NGT group,and the difference has statistical significance(p<0.05).(2)In the same group,the skeletal muscle mass of male in two groups was higher than that of female(p<0.05).(3)According to the age group,the higher the age,the more obvious the decrease of skeletal muscle mass,and the more obvious the decrease of skeletal muscle mass in the T2 DM group compared with the control group(p<0.05).(4)According to the course of disease,the longer the course of disease,the more significant the difference in skeletal muscle mass(p<0.05).The skeletal muscle mass of patients with T2 DM whose course of disease is more than 20 years is the least.(5)The more insulin resistance is,the lower the skeletal muscle mass is(p<0.05).(6)The amount of appendicular skeletal muscle of patients with T2 DM complicated with peripheral neuropathy is lower than that of patients without peripheral neuropathy((p<0.05),and the possibility ofsarcopenia is higher.(7)Logistic regression analysis showed that the regression coefficients of gender,age,course of disease and insulin resistance index(B value)was greater than 0 and OR value was greater than 1 in the T2 DM group(Wald test p<0.05),suggesting that gender,age,course of disease and insulin resistance index were independent risk factors affecting skeletal muscle mass level in the patients with T2 DM.ConclusionThe appendicular skeletal muscle mass in patients with T2 DM decreased more significantly than that in healthy adults.In patients with type 2 diabetes mellitus,as the aging and course of disease growing up,poor long-term plasma glucose control and diabetic peripheral neuropathy,it can significantly affect the amount of appendicular skeletal muscle and increase the incidence of sarcopenia in patients with type 2 diabetes mellitus.It is important to monitor and control plasma glucose actively in daily life,correct bad habits and improve the quality of life,so as to reduce the incidence of muscular dystrophy in T2 DM. |
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