The Effect Of HSP70 Peptide Complexes During Hyperthermia And Immunotherapy Mediated By Cytotoxic T Lymhpocytes On Tca8113 Cells

Backgrounds and Objectives: Carcinoma incidence of tongue and buccomucosa is much higher among the head and neck tumor patients. The suffering patients treated by surgical procedures combinated with radio-chemiotherapy and the survival rate in tumour stage I and II is between 50 and 60%. nevertheless, at the anvanced stage it drop down to no more than 30%, thus it is very important to find out a new type of treatment avoiding disfigurement and disfunction of head and neck in order to improve the survival rate and quality; It is well documented that the expression of HSPs correlates to thermotolance, which is due to blind zone of antitumor, therefore, how to degrade the expression of HSPs is a criticality to better the therapeutic effect of thermotherapy.HSPs can deliver antigen into the MHC-I presentation pathway of antigen-presenting cells (APC), thus stimulating antigen- specific CD8~+ T-cell reactions. To our knowledge, the tumor cells can escape the immune surveilliance because tumor antigens remain immunologically hidden in the progressively growing tumor. Killing tumor cells release tumor antigens from the cells have been demonstrated to generate potent antitumor immunity. The effect is determined partly by the levels of HSP...