Effects Of CX/GJIC On Rat Hepatic Oval Cells

BackgroundThe hepatic injury is a prevalent complications after burns. The degree of hepatic injury and dysfunction have an intimate relationship with the degree of the burns. During liver regeneration after liver damage, quiescent hepatocytes undergo replication to restore the liver mass by a process of compensatory hyperplasia. However, if the regenerative capacity of mature cells is impaired by liver-damaging agents, liver stem cells are activated and expanded into the liver parenchyma that reveals promising prospects in the treatment of liver failure, possessing potent proliferating capacity and multi-potential differentiating capacity. Liver stem cells also have an intimate relationship with hepatoma, which research on stem cells has recently indicated. So the research to elucidate the regulative mechanism of proliferation and differentiation of liver stem cells is a thrilling and challenging field.GJIC mediated by CX is the pivotal pattern of communication in multicellular organism and is considered to specifically correlate in the control of virtually all aspects of the damage and regeneration in tissue. Gap junctions provide a pathway for direct intercellular communication that includes the passive diffusion of small (<1000 Da) and hydrophilic molecules,...