"Winter Diseases Being Cared In Summer"-Theory And Practice On The Traditional Chinese Medicine "Prevention Of Disease"

THE PART OF CLINICAL OBSERVATIONOBJECTIVEAccording to TCM theory and the treatment of disease based on the concept of Yang Yang in the spring and summer, Yang Yin in the autumn and winter, the use of Winter Disease Control Point Application therapy in children with asthma in remission. Through the observation experience square patches volts meridians (Da Zhui, bilateral Dingchuan, bilateral Feishu, bilateral spleen, bilateral Shenshu) Application on the clinical symptoms of asthmatic children, red blood cell C3b receptor rosette (RBC-C3bRR), red blood cell receptor immune complex rosette (RBC-ICR), tumor necrosis factor-α(TNF-α), non-specific immunoglobulin E, colony stimulating factor (GM-CSF), Thl, Th2 cells factor IFN-γ, IL-4 in vitro and deposited with the effect of the exact spirit of the traditional formulations of asthma(paste) to compare, apply spirit of traditional Chinese medicine asthma control point application patches remission of asthma in children and its possible role in clinical mechanism, so as to apply the Spirit of Chinese medicine formulations of asthma improved the feasibility and provide the basis for clinical application. METHODS60 cases were selected from July 2009 in Hubei Province Chinese Medicine Hospital pediatric outpatient children, in line with Western diagnostic criteria for children with asthma in remission and case inclusion criteria. Will apply in all cases randomly assigned to breathe Point Application Dog Days soul patch group and Budesonide Aerosol treatment group,30 patients in each group.All asthmatic patients in remission according to Chinese standards and classification of disease type classification standard for traditional Chinese medicine and disease classification. Two groups of children on gender, age, onset age, duration of disease, illness, TCM syndrome were compared, the statistical P>0.05, no significant differences between comparable. Observation period started from July 2009 to July 2010 only, a total of one year. Group of children were observed during the first V, the second V, volts) deposited on the first day to breathe a soul patch applicator children back Ojo, bilateral Dingchuan, bilateral Feishu, bilateral spleen, and other points of bilateral Shenshu; control group were given Budesonide Aerosol 200μg/times,12 hours, even for 3 months. In addition, patients in the first applicator before and after the observation period were used to detect RBC-C3bRR, RBC-ICR, TNF-α, IgE, GM-CSF, IFN-Y, IL-4 levels were compared before and after treatment the changes in these indicators.RESULTS1. After treatment, could significantly improve the remission of clinical symptoms in asthmatic children(P<0.01), no significant difference between the two groups (P>0.05);2. Observe the groups of different ages, different course and different set of TCM clinical symptoms in children improved after no significant difference between groups (P>0.05);3. Both groups can significantly eleated children remission asthma RBC-C3bRR and reduce RBC-ICR level (P< 0.05), no significant difference between the two groups (P>0.05); 4. Significantly decreased in both groups asthmatic non-specific IgE serum levels (P<0.01) and TNF-αlevels (P<0.01), no significant difference between the two groups (P>0.05);5. Significantly decreased in both groups asthmatic children wi th GM-CSF levels (P<0.05), no significant difference between the two groups (P>0.05);6. The blood in both groups significantly decreased IL-4, increased IFN-γlevels (P<0.05), no significant difference between the two groups (P>0.05).CONCLUSION1. Dyspnea can significantly improve the spiritual deposited immune function, reduce the release of inflammatory mediators to control asthma attacks;2. Panting spirit adjustable deposited cellular immune status of children, improve immunity and resistance in children, reduce the number of colds and asthma attacks degree, reduce the degree of asthma attacks.The mechanism may be by regulating T cell function in children, thereby regulating T lymphocyte secretion of IL-4, IFN-γand other cytokines, inhibiting the synthesis of IgE in children to achieve;3. Asthma is effective against the disease spirit deposited, the dose is accurate, easy to use, health economics, is worthy of clinical application. THE PART OF EXPERIMENTAL RESEARCHOBJECTIVEObserve the effects of point application mainly to improve the treatment of allergic rhinitis in rats scratching the nose, sneezing, rhinorrhea and other symptoms of allergic rhinitis in rats to promote the growth and development, to improve ventilatory function in rats with allergic rhinitis, allergic rhinitis, decreased IgE and ECP level of regulation of serum IL-2, IL-4, IL-6, INF-γlevels and ICAM-1, VCAM-1 expression levels and other indicators, From the cellular and molecular level of Acupoint Application on the immune regulation of allergic rhinitis mechanism for scientific and effective treatment of allergic rhinitis provide a theoretical basis.METHODSIn this study, young SD rats were randomly divided into four groups:normal control group (control group), model group (model group), oral dexamethasone group (group B), point application group (experimental group).Sticking drugs:Chinese honey locust, Sinapis alba, Huang Qi, The lily magnolia is colored, Achene of xanthium sibiricum, Asarum, Fumitory, Ginger juice.Point selection:Ojo, Feishu, spleen, internal relations.Double antibody sandwich ELISA method in each group immunoglobulin E (IgE), eosinophil cationic protein(ECP) levels and cytokines (IL-2, IL-4, IL-6, IFN-γ),cells adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) expression. Nasal mucosa were observed pathological changes and rat nasal mucosa in the number of eosinophils, neutrophils and lymphocytes.RESULTS 1. Experimental group and model group than in the IgE, P<0.01, there was significant;2. Western group and model group than in the IgE, P<0.01, there was significant;3.Experimental group and the western medicine group than in the IgE, P<0.05, statistically significant;4. Experimental group and model group than in the ECP, P<0.01, there was significant;5. Western group and model group than in the ECP, P<0.05, statistically significant;6. Experimental group and the western medicine group than in the ECP, P>0.05, no statistically significant;7. Experimental group and model group than in the IL-2, P<0.01, there was significant;8. Western group and model group than in the IL-2, P<0.01, there was significant;9. Experimental group and WM group than in the IL-2, P>0.05, no statistically significant;10. Experimental group and model group than in the ICAM-1, P<0.01, there was significant;11. Western group and model group than in the ICAM-1, P<0.01, there was significant;12. Experimental group and WM group than in the ICAM-1, P<0.05, statistically significant.CONCLUSIONExperimental studies have shown:the experimental group and model group can effectively reduce IgE levels, and the experimental group and western medicine group were statistically significant; experimental group and model group can effectively reduce the ECP level, but the experimental group was more apparent; experimental group and model group can effectively increase IL-2 levels, but the experimental group was more apparent; experimental group and model group can effectively reduce the level of ICAM-1, and the experimental group and western medicine group were statistically significant.