Research On The Bupleurum Class Fangfang Card Law, Based On Data Mining

The research of law between Formula and Syndrome about Bupleurum Analogous Formulas based on data mining methodWith the guidance of the theory of relation between Formula and Syndrome, using the Bupleurum Analogous Formulas as the study object, the researcher builds the data base of Bupleurum Analogous. Adopt frequencies, associative rules and cluster analysis to excavate the formula syndrome rules and category relationship of Bupleurum Analogous.Research 1:The research of law between Formula and Syndrome about Bupleurum Analogous Formulas based on frequency analysisMaterials:Using the Proprietary Chinese medicine dictionary as the material source, with the premise of Analogous Formulas definition. Methods:Select the eligibility formula, around the information of formula-medicine and disease -syndrome, which include the formula name, formula source, formula medicine, dosage, formulation, usage and symptom, disease reason, pathogenesis, disease name, etc. According to the Clinic Terminology of Traditional Chinese, the Chinese herbal, Noun of TCM, Differential diagnostics of TCM syndrome, TCM symptoms differential diagnostics, to standardizing the formula-syndrome information and build the Bupleurum Analogous data base.Using the function of query, achieve the statistics the frequencies of any kinds of the database. Results:(1) The formula-medicine frequency analysis shows that 185 medicines can be found in all the formulas. The frequency analysis shows that the high frequency medicine including:radix bupleuri, scutellaria, glycyrrhiza, ginger, peony, pinellia, ginseng, poria, tangerine peel, rhubarb, angelica, gardenia, jujube, radix ophiopogonis, bitter orange, rehmannia, atractylodes macrocephala, rhizoma anemarrhenae, radix puerariae, gypsum, rhizoma, mirabilite, ligusticum wallichii, rhizoma coptidis, fructus aurantii immaturus, platycodon grandiflorum, radices trichosanthis, mangnolia officinalis, bamboo leaf, radices sileris, radix astragali, cortex lycii radicis, cortex cinnamomi, pericarpium citri reticulatae viride, rhinoceros horn, cortex moutan, cassia twig, rhizoma zingiberis, turtle shell, rhizoma alismatis, felwort, oriental wormwood, trichosanthes kirilowii Maxim, rhizoma seu radix notopterygii, areca-nut, rhizoma atractylodis, akebiaquinata, amomum tsao-ko, grifola, mentha haplocalyx. The frequency statistic shows that the high frequency compatible structure including benefit, relieving exterior syndrome, clearing heat, reducing phlegm, promoting the circulation of qi, remove dampness through dieresis, galactic, resolving dampness, inner worming, invigorate the circulation of blood. The high frequency combination including:scutellaria +radix bupleuri, glycyrrhiza +scutellaria, glycyrrhiza +radix bupleuri, ginger +scutellaria, ginger +scutellaria, paeonia +scutellaria, paeonia +radix bupleuri, pinellia ternata+scutellaria, pinellia ternata+radix bupleuri, ginger +lycyrrhiza, ginseng +scutellaria, ginseng +radix bupleuri; glycyrrhiza +scutellaria +radix bupleuri, ginger +scutellaria +radix bupleuri, paeonia +scutellaria +radix bupleuri, pinellia ternate +scutellaria +radix bupleuri, ginger +glycyrrhiza +radix bupleuri, ginger+ glycyrrhiza +scutellaria, ginseng+ scutellaria +radix bupleuri. The dosage statistic shows that decoction is the most. Pill powder using transfer media include congee, ginger decoction, water soup, worm water, gruel, boiling soup, gingertea, Dwarf lilyturf soup, warm wine. (2) Disease and syndrome statistical results show that:disease signs involves in 532 formulas, the 657 formula involved in the pathogenesis of 155 formula, formulas involved in the etiology describe 259 formula, formulas involved in the disease narrative 433 formula, the most are alternate chills and fever, fever, headache, thirsty, vomiting, upset, only hot, loss of appetite, be agitated, pulse string, pulse fast, constipation, hot flashes, cough, limb pain, dry mouth, bosom frowsty, pleura pain. For the high frequency of disease combination appears for a major disease combination:vomiting+alternate chills and fever, pulse fast+pulse string, urination+constipation, mouth bitter+alternate chills and fever, pulse string+ alternate chills and fever, only hot+headache, limbs pain+loss of appetite, deafness +mouth bitter, loss of appetite+alternate chills and fever, vomiting+headache, thirsty+fever, upset+vomiting; deafness+mouth bitter+alternate chills and fever, pulse fast+pulse string+alternate chills and fever, deafness+mouth bitter+pleura pain, mouth bitter+vomiting+alternate chills and fever, mouth bitter+pulse fast+ pulse string, loss of appetite+vomiting+alternate chills and fever, deafness+pleura pain+alternate chills and fever, mouth bitter+pleura pain+alternate chills and fever, upset+vomiting+alternate chills and fever, mouth bitter+pulse fast+alternate chills and fever. The pathogenesis appear the top 10 times including heat into the blood room, less Yang unsuitable, liver and guts heat, chest with heat interference, suffered inflammation, stomach heat, spleen and stomach deficiency, hot phlegm, deficiency of blood, wind-heat of less Yang, etc.; the reasons of disease appear among them the top 10 times including the etiology of typhoid fever, epidemic disease, cold, phlegm retention, pregnancy anopheles evil, anger, constitution, fatigue, labor, anopheles evil; the disease appear among them the top 10 times including malaria, typhoid fever, fever, plague, virtual fatigue, jaundice, colds, exogenous febrile disease, pregnancy and malaria, wild diarrhea.Research 2:The research of law between Formula and Syndrome about Bupleurum Analogous Formulas based on correlation analysisMaterials:Ditto. Methoeds:With market basket analysis tool, find the association rules. Results:Correlation analysis shows that the main connection including agaric ? rhizoma alismatis, amomum tsao-ko→mangnolia officinalis, ephedra→gypsum, pericarpium citri reticulatae viride→mangnolia officinalis, ephedra→the root of kudzu vine, herba artemisiae capillaris→jasmine, mirabilite→rheum officinale, Ligusticum wallichii→rehmannia, the root bark of the peony tree→angelica sinensis, astragalus mongholicus→ginseng, mangnolia officinalis→pericarpium citri reticulatae, turtle shell→poria cocos, etc. The main correlation symptom including mouth bitter→deafness, pulse string? pulse fast, constipation ? urination, mouth bitter→alternate chills and fever; the main correlation between medicine and symptom including constipation→mirabilite, constipation→rheum officinale, jaundice→jasmine, urination→jasmine, painful abdominal mass→pinellia ternate, limbs pain→radix ophiopogonis, urination→rheum officinale, spontaneous perspiration→pericarpium citri reticulatae, deafness→pinellia ternate, constipation→glycyrrhiza and rheum officinale, mouth dry→paeonia and glycyrrhiza, etc.; the main correlation between medicine and disease including icterus→oriental wormwood, virtual fatigue→astragalus, amenorrhoea→angelica, contempt when pregnancy→radix ophiopogonis, malaria when pregnancy→rhizoma atractylodis macrocephalae, virtual fatigue→angelica, fever→pericarpium citri reticulatae, etc.Research 3:The research of law between Formula and Syndrome about Bupleurum Analogous Formulas based on cluster analysisMaterials:Ditto. Methods:With market category detection tool, find the category information. Results:Analysis by synthesis showed that:(1) The bupleurum analogous formulas shows 5 formations as clearing YangMing+nourish yin and abatement of fever, Qi dry wet+the wet water permeability spleen, nourishing blood and promoting blood flow+cool the blood dissipate blood stasis, Xiao Chaihu Tang's structure, diarrhea fever and relaxing the bowels+clearing liver-gallbladder and adjust the movement of qi. (2) The bupleurum analogous formulas shows 7 syndromes as extra cool and inner hot, original of shaoyang, muggy of shaoyang+ incoordination between the spleen and the stomach, rising of wind-hot, heart sutra hot filled, tri-jiao hot filled, yin asthenia generating intrinsic heat+tri-jiao stasis. (3) The bupleurum analogous formulas shows 4 medicine-syndrome combinations as harmonize the stomach+clearing fever and promoting blood flow with muggy of shaoyang, tonifying qi and yin+clearing a way heat and reducing fire with yin asthenia generating intrinsic heat, clearing and relaxing the bowels with tri-jiao closed because of the heat, clearing damp+tonifying spleen with damp and hot resistance+ lift disorders.Indications:The study indicates that bupleurum analogous formulas was related to infectious disease, lung disease, taste of disease, liver disease, encephalopathy, parasitic diseases, pediatric diseases, pregnancy and postpartum disease, ent, surgery illness skin disease; the treatment of disease and syndrome involves the main causes are cold, epidemic disease, anopheles evil; chills and fever and deficiency-excess complication are the main pathogenesis feature, the most involving heat into the blood room, less Yang unsuitable, liver and gallbladder heat, stomach and chest heat, spleen and stomach deficiency, hot phlegm, etc. The center of the symptoms involves alternate chills and fever, mouth bitter, pulse string or fast which has the relationship of combination with fever, headache, thirsty, upset, vomiting, loss of appetite, constipation, cough, myalgia and bosom frowsty and hypochondriac pain.The above 3 researches showed that the compatibility of bupleurum analogous formulas was related to benefit, relieving exterior syndrome, clearing heat, reduce phlegm, promoting the circulation of qi, flow swiftly, resolving dampness, inner worm, invigorate the circulation of blood.The medicine group and the disease, pathogenesis, symptom showed some relevance. The clustering analysis hints of bupleurum analogous formulas within category features of medicine and symptom.Conclusion:The data mining technology used to study the formula syndrome rules of analogous formulas has certain feasibility.