| Pterocephalus hookeri (C.B.Ckarke) Hoeck is a common Tibetan medicine, its another name is "Bang Zi Du Wu". It can clear away heat and detoxify, remove rheumatism, relieve pain, and be always used to cure the fever caused by external influences and rheumatism, so it is used extensively in compounded Tibetan medicine. 《Pharmacopoeia of the People's Republic of China》 1977 edition (I part) 《Tibetan drug standard of the People's Republic of China (one part)》 record Pterocephalus hookeri (C.B.Ckarke) Hoeck .Ranjianduoji capsule is an experiential prescription of national level doctor Tangka..Ang'wengjiangcuo he lives in Ganzi Tibetan hospital of Sichuan province. This capsule can mitigate symptom about pain and joint being infective which are caused by rheumatiod arthritis. It is used many years in clinic by water pallet, the main herb in this prescription is Pterocephalus hookeri (C.B.Ckarke) Hoeck.There are a lot of reports about chemistry research of Pterocephalus hookeri (C.B.Ckarke) Hoeck, but the chemical ingredient can't combine with pharmacodynamics test, these can not reveal the matter basic of antiaflammation and abirritation, and it isn't index ingredient of quality standard either, so these can't be connect with the function and treatment of Pterocephalus hookeri (C.B.Ckarke) Hoeck. There are also many reports about pharmacognosy, 《Tibetan drug standard of the People's Republic of China (one part)》the term of P. hookeri (C.B.Ckarke) Hoec?is short of not only determining content but also TLC identification. In order to find out effective component curing rheumatoid arthritis and offer effective methods for empoldering, combining with the theory of Tibetan medicine and clinic practise, relating botany, chemistry and pharmacology, using the method of HPLC-DAD, GC-MS and radioimmunoassay, we did research from geographical resource distributing. pharmacology, chemical constituents and quality controlling about Tibetan medicine P. hookeri (C.B.Ckarke) Hoeck.. and Ranjianduoji capsule. We put forward the thoughts about Tibetan drugs' basic research and resource protecting. This research has special social meaning and higher methodological meaning. 1. Herbal evident and document checkInquire the documents of first record about the function and treatment and breed of P. hookeri (C.B.Ckarke) Hoeck. Correct the error about breeds and record of P. hookeri (C.B.Ckarke) Hoeck. in 《Jingzhu Herbal》 and. 《Chinese Herbal Tibetan medicine part》 It offer objective basis for researching clinical apply and quality standard of P. hookeri (C.B.Ckarke) Hoeck. furtherly. 2.Resource geographical distributing investigationOn autoptical research in Tibet. Qinghai. Gansu, Yunnan and Sichuan, be sure the entironment and geographical distribution of P. hookeri (C.B.Ckarke) Hoeck .Through the geographical distributing investigation of resource, we knew zone distributing of Tibetanmedicine P. hookeri (C.B.Ckarke) Hoeck. locates middle part and east of intersectingmountain in southwest and northwest parts in China.3.Microscopical identificationMicroscopical observe the tissue cross of root and leaf of P. hookeri (C.B.Ckarke) Hoeck.Combining with research of quality standard, Microscopical identify power of P. hookeri(C.B.Ckarke) Hoeck. and Heracleum hemsleyanum Diels in Ranjiangduoji capsule.4.Chemical Constituents researchFirstly combining with track of antiaflammation and abirritation pharmacodynamics test, Fourcompounds were isolated from . P. hookeri (C.B.Ckarke) Hoeck. by using solvent separatemethod, and column chromatography. According to structural analyse of melting point, IR, Ms,'H-NMR and 13C-NMR etc. they are elucidated as Oleanolic acid.,6-sitosterol and rivularicin.Rivularicin is first found out from P. hookeri (C.B.Ckarke) Hoeck..5.physicochemical analyseThe total contents of ursolic acid and oleanolic acid were measured by thin layer scanning ; thecontent of ursolic acid and oleanolic acid is used by HPLC; the contents of saponin in P.hookeri (C.B...
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