Compound Cat Milk Powder Hyperuricemia And Gouty Arthritis Pharmacodynamic School And Part Of The Mechanism

The compound Maoru powder was choosed to treat hyperuricaemia and gouty-arthritis from a great deal of Tibetan proved recipes for the first time under the guidance of TCM and Tibetan medicine theory. It was original for there were no similar drugs in the market.This research concluded of chief pharmacology experiments and mechanism study. The results showed:1. It could reduce the uric acid of hyperuricaemia animal model and inhibit xanthenes oxidation enzyme(XOD).2. It could markedly relieve the swollen foot of animal model of gouty-arthritis, reduce the content of TNF-α, IL-1β , IL-6 in ankle joint, increase the content of 5-HT and DA in nerve centre and reduce the content of 5-HT and DA in blood serum.3. It could remarkably decrease the twist-reaction stimulated by acetic acid, enhance the pain threshold induced by heat irritation.4. It could restrain the inflammation induced by egg white, dimethylbenzen, and tampon. All the results indicated that it had good effects on gouty arthritis and hyperuricaemia. Its treatment of hyperuricaemia had something to do with depressing XOD. The mechanism of anti-gout was decreasing the content of TNF-α , IL-1β , IL-6 in ankle joint. Its effects of abirritation and anti-inflammation was owing to adjusting the content of 5-HT and DA.Maoru and Ruxiang are discovered for the first time that it has good effect of lowering uric acid, which is original found of its function. With its further clinical application, it could developed into new drug to cure hyperuricaemia and gouty-arthritis and had academic value for this kind of Chinese medicine to develop their function theory.Taking apart experiment of Maoru Powder was done for the first time to find more effective drugs or more effective combinations.