Pungent Bitter Drop The France Huoxuetongluo Improve The Clinical And Experimental Studies Of Type 2 Diabetes Islet Function,

The main pathological mechanism of type 2 diabetes(T2DM) are insulin resistance (IR)and impairedβ-cell function, and now we think only if IR can't cause diabetes, it must has impairedβ-cell function simultaneously, IR is the starting factor and impaired ofβ-cell function is decision factor. The impairedβ-cell function is always exist, not only in DM period, but also in prediabetic period and the group of non-diabetic fist relatives of patients with T2DM.The cause of impairedβ-cell function is very complex, the main cause are glucotoxicity,lipotoxicity and inherit factor etc. They can increase theβ-cell burden, or /and decreaseβ-cell number, change the quality, quantity and phase ofβ-cell, and then can't maintain the blood sugar level. Glucagon-like peptide-1(GLP-1) is one of the hot point of research of DM in recent years, it can regulate blood sugar by complex mechanism, including insulin and glucagon secretion, gastric emptying and insulin sensitivity, increase the quantity ofβ-cell and inhibit it's apoptosis, and the improveβ-cell function and IR.The traditional Chinese medicine is consistent with guidance principle of therapy, which improveβ-cell function by the compound factors of decreasing bloody sugar, blood cholesterol and remedy metabolic disorder. In the light of present therapeutic situation, the Chinese medicine have a certain advantage in improvingβ-cell function. So our research observes the xinkaikujiang, huoxuetongluo methods'effect on improvingβ-cell function and explains its mechanism initially by clinical research and experiment research.In the part of theoretical study, the pathogenesis ofβ-cell function of T2DM, the study methods, the present therapeutic study of Chinese and western medicine were summed up. It argued the train of thought and methods which prevent and cure impairedβ-cell function of type 2 diabetes, explaining the effect mechanism and the rule of Chinese medical principle and cure from the xinkaikujiang, huoxuetongluo methods through the modern and archaic documentary record examined from each Chinese department and school, which is reviewed and summarized.。This clinical part based on the observation in the long term by teacher. Xinkaikujiang formula is formed and based on ganjianghuangqinhuanglinrenshen formular and didang formula from . The patients who have fat shape of T2DM and have the symptom of spleen deficiency ,liver stagnation and blood stasis are adopted for study object by the clinical method of single blindness...