Depression Shu Antidepressant Effect And Related Efficacy Studies

Depressive syndrome is a group of pathological conditions characterized by in common by the depressive mood state .Diseases as mood disorders (depression, mania) and other psychiatric disorders are included, and could be presented in other pathologies. It's a syndrome of high incidence, difficult to treat, and will cause great loads to the helth of patients and their families. Tt has causes a great impact among the world. Chinese traditional medicine makes great results to ameliorate this syndrome with little side effects in recent years. But, the choosing criteria of correct formula to treat depressive syndrome are dispersive for now. So, it is difficult to popularize that.In this study, Yiyushu and Rhizoma Cyperis are compared for their possible antidepressant effect in animal models as: tail- suspension model of mice, forced swimming models of mice and rat, and reserpine induced depression model in mice, as well as their anti-fatigue, depressant activity of central nervous system and hypnotic activity. Results of the research can probe:1 Yiyushu shows important effects compared with control group in forced swimming model of mice, tail- suspension model of mice and reserpine induced depression model. In the same time, Rhizoma Cyperis shows significant effects in tail- suspension model of mice and forced swimming model of rats. The above results suggest that Yiyushu could have significant effect for treatment of depressive syndrome.2 Yiyushu clearly elevates concentrations of noradrenalin (NA), dopamine (DA) and serotonin (5-HT) of brain in mice under depression status caused by reserpine, suggests that Yiyushu could improve depressive status through elevations of the monoamine neurotransmitters.3 Yiyushu evidently prolongs the swimming time and superoxide dismutase...