Vegf In Acute Myeloid Leukemia, The Expression Of Meaning And A Different Indigo Leukemia Anti-angiogenic Effect

Angiogenesis is the process in which new microvessels form from preexisting ones .It has been well established that angiogenesis is one of the most potent factors involved soild tomors growth expansion, invasion and metastasis. Some soild tumors, such as breast cancer and colon carcinoma, are dependent of angiogenesis. Previous studies have demonstrated that vascular endothelial growth factors (VEGF) and basic fibroblast growth factor (bFGF) are important potent factors in tumors-associated angiogenesis.Recent studies have further shown that VEGF and bFGF effected the tumor growth by stimulating endothelial cell proliferation and migration.It has now become evident that angiogenesis play a key role in some hematological maliganancies. Furthermore, the plasma concentration of VEGF and bFGF in leukemia patients are associated with unfavourable prognosis.Myeloid leukaemic cell was selected in Our study, and investigated on three lines below① Expression of VEGF,bFGF and their receptors in BMMNCs of acute myelocytic leukemia patients was detected by RT-PCR② Observing the effect of VEGFon the proliferation and apoptosis of leukemic cells.③The high VEGF concentration in the bone marrow of CML patients prompt us to find wether meisoindigo inhibit angiogenesis.Result1 In primary AML patients, more than 50% expressed transcripts of VEGF , approximately 50% patients expressed Fltl , about 1/5 patients had transcripts of bFGF and it's receptors, rare patients expressed transcripts of KDR. Mean VEGF plasma concentrations in primary AML patients(154.75 ± 109.98pg/ml) was significantly higher than patients with CR(72.05 ±23.39pg/ml) and normal controls(99.91 ± 41.87pg/ml).Among 75 primary AML patients who received regular chemotherapy,...