Hypertension Susceptibility Gene Polymorphism Associated With The Metabolic Syndrome And Metabolic Syndrome

Objectives To determine factors associated with hypertension awareness, treatment and control in Chinese rural adults aged 40-75 years. It was also to determine whether status of hypertension is associated with metabolic abnormalities and moderate renal dysfunction (MRD). Methods In order to investigate factors associated with hypertension awareness, treatment and control in Chinese rural adults, a cross-sectional study was carded out. Total 4630 patients with hypertension and 930 age-sex matched people without hypertension were recruited; age 40-75 years, from 7 rural communities. Hypertension was defined as systolic blood pressure (SBP)≥140mmHg, or diastolic blood pressure (DBP)≥90mmHg, or history of antihypertensive drug use. Awareness was defined as hypertensive patients reported previous diagnosis of high blood pressure by a physician. Treatment was defined as reported current use of antihypertensive drug therapy. Control was defined as antihypertensive drug treatment associated with SBP＜140 mmHg and DBP＜90 mmHg.Results In hypertensive population, 79.8% were aware of their diagnosis, 68.8% were receiving treatment, but only 5.9% of all participants with hypertension, 8.6% of those receiving treatment were controlled. Higher awareness and treatment were noted for participants with history of stroke, diabetes mellitus, coronary artery disease (CAD), family history of cardiovascular disease (hypertension, stroke and CAD), and older, former drinking (treatment). Among all participants with hypertension, the odds ratio (95% CI) of hypertension control was 0.68 (0.49, 0.92), 0.45 (0.32, 0.63) for persons in the two older age groups: 50-59 years, 60-75 years, respectively, compared with the younger age group: 40-49 years, 1.72 (1.18, 2.50) for those who had history of CAD, 1.86 (1.21, 2.85) for persons who had family history of CAD. Metabolic syndrome, obesity and MRD were more frequent in controlled hypertensive subjects than in normtensive subjects. In persons with treatment, compared to the controlled hypertension, uncontrolled hypertension showed a greater prevalence of impaired fasting glucose, provisional diagnosis of diabetes,obesity.Conclusion In Chinese rural adults, although hypertension awareness and treatment are better than before, control is limited. The control of blood pressure (BP) is crucial in the prevention of metabolic abnormalities, especially impaired fasting glucose. Objectives To investigate the relationship between single nucleotide polymorphism(SNP) C19012T of ribosomal protein S6 kinasel (S6K1) gene and overweight in a Chinese rural population, as well as to determine whether C19012T is associated with serum total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) level in overweight population.Methods Genotyping for C19012T was completed by using PCR, restrictive enzyme digestion, and sequencing in 1097 overweight patients and 699 normal weight control were selected according to classification from the prevention and control guideline of Chinese adult overweight and obesity by China Obesity Task Force (overweight: Body Mass Index (BMI)≥24Kg/m~2; normal weight: 18.5Kg/m~2