The Academic Experience Of Professor WangChanghong In Treating Ulcerative Colitis

Ulcerative Colitis(UC) is a kind of non-specificity chronic inflammatory disease of colon.It is consider as a refractoriness digestive disease.Professor Wang Changhong achieved a great deal of experience in the treatment of UC. This article summary systematically on advisor' academic experience from theory research,clinical research and experimental research.On theory research,the researcher summarized on the origin and pathogenesis of a disease and therapeutic methods on history,and reviews the clinical experience of professor Dong Jianhua in treatment of diarrhea.Warm and clear is the main method of Dong Jianhua in treatment of UC.Based on this theory,Professor Wang Changhong considers that the pathogenic foundation is spleen asthenia,the pathogenic condition is heat and toxicants,and the pathology product is blood-stasis.According to this thought,advisor treats UC with the method of strengthening the spleen and supplementing Qi,clearing away heat and toxicants resolving blood-stasis and unblocking collaterals.In each pathological phases of UC,Professor Wang Changhong uses the method of eliminating the evil in the initial stage,and at the same time,the method of invigorating the spleen is also used.In the later stage,the method of invigorating the spleen is important, the method for eliminating damp or blood stasis also be used.Advisor created the foundation prescription which is composed of Radix Astragali 30g,Radix Astragali10g,Rhizoma Zingiberis Preparata10g,white flower patrinia harb20g, Radix Pulsatillae15g,Rhizoma Coptidis10g,Indigo Naturalis10g,Radix Sophorae Flavescentis15g,Rhizoma Atractylodis Macrocephalae15g,Rhizoma Atracylodis15g,Rhizoma Chuanxiong10g,Radix Salviae Miltiorrhiae15g,Radix Glycyrrhizae preparata10g. On clinical research,forty patients with UC were randomly divided into tow groups.Twenty patients in the Chinese herb group were give Chinese herb medicine of strengthening the spleen and supplementing Qi,clearing away heat and toxicant resolving blood-stasis and unblocking collaterals.Twenty patients in the Western medicine group were treated with Etiasa.Then the curative effect was observed.The comprehensive clinical efficacy,the mucosal diseased efficacy and the clinical efficacy on symptoms of the Chinese herb medicinal group was better than that of the Western medicine group(P＜0.05).Compared with the Western medicine group,the improvement of the main symptoms(diarrhea,tenesmus) and the mucosal diseases(erosion,ulcer) before and after treatment were statistically significant(P＜0.01).The prescription of Professor Wang Changhong in treatment of UC is effective on the clinic.On experimental research,the prescription can effectively improve the symptom and pathological change of TNBS-induced UC rats.The effect of synthetic group to improve the clinical symptoms and to lighten the injury of naked eye and histology is better than that of Sodium Chloride group(P＜0.05,P＜0.01).The effect of synthetic group to improve the clinical symptoms such as the weight degression,diarrhea and to decrease the disease active index is also better than that of SASP group(P＜0.05).Compared with the Yiqijianpi group, the effect of synthetic group to improve the clinical symptoms such as the weight degression,to decrease the disease active index and to contract ulcer area is statistically significant(P＜0.05).The rationality and validity of the prescription is also being proved from the experimental research.