The Experiment Research On Influence Of Crp,IL-6,MMP-9 By Kangmai Soft Capsule Treating The Rabbits With Atherosclerosis Obliterans

Objective:1.Successfully established rabbit model of atherosclerosisobliterans shares.2.Through animal experiments to observe the Kangmai softCapsule of the rabbit model of atherosclerosis obliterans of serum C-reactiveprotein,IL--6,matrix metalloproteinases-9,thromboxane B₂,to increase 6-keto-prostaglandin_1α the impact of Kangmai soft Capsule to explore the treatment of softgelatin capsules arteriosclerosis obliterans mechanism.Methods:The"high-fat diet,""electric burn injury in femoral artery intima,""femoral artery ring reduction,""bovine serum albumin intravenous immune injury"means composite made of"Rabbit Femoral Arteriosclerosis Obliterans"model;successful model 54 New Zealand white rabbits were randomly divided intoKangmai soft Capsule treatment group,the treatment Tongsaimai model group andblank group(no treatment) three groups of 18;administrat:Kangmai soft CapsuleGroup A:0.56 / Kg,diluted with saline 10ml/Kg,orally,once a day;Tongsaimaitablets group:0.75 / Kg,diluted with saline 10ml/Kg,orally,once a day.Modelgroup:normal saline,10ml/Kg,orally,once a day.Every morning in each group inaccordance with the standard oral administration 10ml/kg time.Model adopted bypathology,ultrasound,angiography and TXB₂,6-K-PGF_1αtesting to verify theindicators of the animal model of success;the application of ELISA detection modelof the three groups before and after administration of serum C-reactive protein,IL-6,matrix metalloproteinases-9 changes.Results:1,by pathology,ultrasound,angiography and TXB₂,6-K-PGF_1αdetection indicators confirmed the successful establishment of animal models.2,Kangmai soft Capsule can reduce the share of soft capsules arteriosclerosisobliterans rabbit serum C-reactive protein,IL-6 and matrix metalloproteinases-9and lower thromboxane B₂,to increase 6-keto-prostaglandin_1α,and significantlysuperior Tongsaimai tablets in the treatment group(P＜0.01).Conclusion:1,in accordance with the relevant indicators to judge the successof the model,in line with the standard model of arterial occlusive disease,can berelated to inflammatory markers and the relationship between arteriosclerosis obliterans judgments.2,Kangmai soft Capsule by reducing the serum C-reactiveprotein,IL-6,matrix metalloproteinases-9 and lower thromboxane B₂,toincrease6-keto-prostaglandin _1α,arteriosclerosis obliterans of the occurrence anddevelopment of a very good inhibitory effect,plays an active role in treatment.