Study Of The Intervention Effect Of Yangxin Tongmai Mixture On Congestive Heart Failure In Rats

In this study, a generally accepted animal model of Wistar rats with CHF is successfully reproduced with the method of intraperitoneal injection of adriamycin. The animal model is divided into four groups for mechanism study: Yangxin Tongmai mixture of high-dose group, middle dose group, low-dose group and captopril group; blank group and model group are also established as controls. The results show that Yangxin Tongmai mixture can enhance the diastole function of myocardium and thus improve the abnormal hemodynamics of CHF rats; by inhibiting the activation of neuroendocrine and adjusting cytokines of CHF rats, Yangxin Tongmai mixture can thus reverse left ventricular remodeling in rats; it is able to reduce the blood stasis in CHF rats' tissues and organs, reduce the ponderal index of heart, lung and liver, therefore effectively improve myocardial pathologic changes and ultrastructure; it can inhibit myocardial MMP-3 protein expression, promote TIMP-1 protein expression,which is probably the main mechanism that resists myocardial fibrosis; through inhibiting myocardial Bax protein expression and promoting Bcl-2 protein expression of CHF rats, it can inhibit myocardial apoptosis. In conclusion, this prescription can carry out effective prevention and treatment of CHF from multi levels and approaches.