Theoretic Research Analyzed By Syndrome In Etiopathogenisis And Pathogenesis Of "Toxin" Recorded In

【Objective】This paper concludes the significance,pathogenesis, characteristic,syndrome,evolving regularity and therapeutical principle of toxin and genealogical classify the clauses about toxin in the〈Treatise on the Causes and Manifestation of Diseases〉using the research method of bibliography, metrology,taxonomy,conception,statistics and annotation.The genealogical research in toxin in this paper consummates and develops the theory of toxin.【Material & Method】We retrieval the content of〈Treatise on the Causes and Manifestation of Diseases〉using the key word of "Du" and set up database of〈Treatise on the Causes and Manifestation of Diseases〉about "toxin" related to etiopathogenisis.In the process of retrieval we take the〈Treatise on the Causes and Manifestation of Diseases〉published by People' s Medical Publishing House in 1991 and checked by Ding Guangdi as the original,the electronic book of〈Dictionary of Chinese Medicine〉published by Hunan Electron Media Press as the implement.1.Internalizing Condition:all the clauses searched in〈Treatise on the Causes and Manifestation of Diseases〉with the key word of "Du"2.Rejecting Condition:A."Du" not mentioned in the parts of etiological factors;B."Du" mentioned in the parts of etiological factors,but no identified description of the etiological factor;C."Du" mentioned in the parts of etiological factors,with the identified description,but no record of the syndrome.3.Establish and Register Data Bank This paper establishes a databank of the causes and syndrome related with "Du". The variance includes causes and syndrome.According to the condition,register the coincident clauses,and then check it up.Divide the general data bank into different branches according to the different types of "toxin".In the process of data register,we adequately combined some related causes or syndromes referring to the expertise.For example,in etiological factor insect-snake-bird toxin includes snake toxin,insect toxin,sparrow toxin,parasitic tympanties, beetoxin and so on,and breathing disadvantage includes short breath and breathlessness in syndrome fields.4.Statistics method This paper applies SPSS 11.0 to manage and analyze the data and sets transforming regulation for the dimensions of the related variance to make the analysis more reasonable.Among the data,ones with the syndrome will be signed with 1,and ones without the syndrome will be signed with O.We use the SPSS 11.0 to make frequency statistics and cluster analysis to the clauses which record the disease caused by "toxin" or the syndrome induced by "toxin"5.This paper overall and systematically concludes the significance, pathogenesis,characteristic,syndrome,evolving regularity and therapeutical principle of toxin by the way of bibliography,metrology,taxonomy,conception, statistics and annotation.【Result】1.As the first monograph about pathogenesis and Manifestation,〈Treatise on the Causes and Manifestation of Diseases〉records the 250 clauses about "toxin" There are many records about toxin like bee venom,severe pathogenic cold, yin-yang toxin,ghost toxin,parasitic tympanties,herbal toxicity,insect poison,over 40 kinds.The toxin mentioned over 5 times includes pyretic toxicity (40),poisonous Qi(31),insect-snake-bird toxin(24),wind toxicity(17),food toxin(12),severe pathogenic cold(6),wind-heat toxin(5),vina toxin(5) and damp toxin(5) and ghost toxin(5).Further more,186 clauses talked about the syndromes caused by toxin.2.〈Treatise on the Causes and Manifestation of Diseases〉detailed discussed the pathogenesis of toxin in the 4 aspects of excess and weakness of pathogen and vital Qi,imbalance of Yin and Yang,disorder of vital energy and blood and entrails.There are 27 clauses related to excess and weakness of pathogen and vital QI,10 clauses related to imbalance of Yin and Yang like syndrome of yin-yang toxin caused by seasonal epidemic pathogens,syndrome of pestilent cholera etc.,33 clauses related to disorder of vital energy and blood like syndrome of disorder of stomach-QI and ysentery & diarrhea after enterotyphus, syndrome of thoracic retention in enterotyphus etc.,and 77 clauses related to entrails pathogenesis like syndrome of laryngalgia,syndrome of dysentery and diarrhea after enterotyphus,syndrome of stasis in abdomen caused by seasonal epidemic pathogens etc..3.In〈Treatise on the Causes and Manifestation of Diseases〉there are 15 pieces of clause related to "toxin" in name of disease including syndrome of yin-yang toxin in enterotyphus,syndrome of hydropoisoning and so on.There are 53 pieces of clause related to "toxin" in syndrome including syndrome of yin-yang toxin in enterotyphus,syndrome of yin-yang toxin caused by seasonal epidemic pathogens and so on.4.In〈Treatise on the Causes and Manifestation of Diseases〉there are 27 kinds of common symptoms caused by "toxin" including aching,annoyed,swelling, febricity,non-traumatic hemorrhage,itching,lockjaw,acute thoracic pain in four limbs and so on.The symptom occurring over 15 times includes aching(54), annoyed(50),swelling(48),ulcer(47),dysentery and diarrhea(33),febricity (28),hemorrhage(21),and exanthema maculosum(17).5.Different toxin,different pathopoiesis characters.Unscrambling the clause about toxin in〈Treatise on the Causes and Manifestation of Diseases〉,we classify the pathopoiesis characters of toxin into outbreak,danger,catholicity, affectability,capricious,communicability,internal damaging,refractoriness, vulnerability,seasonality and provincialism.6.〈Treatise on the Causes and Manifestation of Diseases〉records the source and syndrome of 44 kinds of diseases,otherwise relates to the diagnosis of toxin, health cultivation and daoyin,which settles theory foundation for the doctors in later generation to study toxin in all the clinical diseases.7.〈Treatise on the Causes and Manifestation of Diseases〉proposed not only the sterilizing and alexipharmic but also the daoyin technique,sweating process, purgation,inducing vomiting and external treatment of healing wind-heat-damp toxin,wind toxin,vina toxin,pyretic toxicity,hydropoisoning,mild-damp-wind toxin,miasm,toxic Qi,parasitic tympanties arrow poison and wind-damp Yin-yang toxin.8.There are 4 pieces of clause in〈Treatise on the Causes and Manifestation of Diseases〉talked about the toxin of medicine like neutralizing poison, neutralize poison of medicine,vomiting & diarrhea poisoned by soup and parasitic tympanties.【Conclusion】1."Toxin" recorded in〈Treatise on the Causes and Manifestation of Diseases〉refers to the cause of disease,pathogenesis,syndrome,name of disease,drug and treatment.Cause of disease is the most mentioned in book.2.In〈Treatise on the Causes and Manifestation of Diseases〉there are 40 kinds of causes about toxin for example pyretic toxicity,poisonous Qi, insect-snake-bird toxin,food toxin,severe pathogenic cold,wind-heat toxin, and vina toxin.3.Insufficiency of healthy energy is the internal cause of the "toxin" invasion.Pathogenic factor is the important condition.Disproportion of Qi-blood and ying-yang caused by toxin is the key factor and precondition of entrails pathological changes.4.The common syndrome of toxin mainly shows aching,annoyed,swelling, anthracoma,sore,febrility,dysentery & diarrhea,vomiting,non-traumatic hemorrhage,obnubilation and so on.5.The pathopoiesis feature of "toxin" can be described into outbreak,danger, catholicity,affectability,capricious,communicability,internal damaging, refractoriness,vulnerability,seasonality and provincialism. 6.The therapeutical principle and treatment proposed in〈Treatise on the Causes and Manifestation of Diseases〉includes sterilizing,alexipharmacon,daoyin technique,perspiration,therapy for inducing vomiting,external treatment and so on.7.Four clauses about toxin of medicine in〈Treatise on the Causes and Manifestation of Diseases〉refer to "magnitude of toxin","poisonous drug" "tolerating toxin" and "toxin in aconiti sinensis tuber".8.The records about "toxin" in〈Treatise on the Causes and Manifestation of Diseases〉contain all the branch of the clinical medicine.The toxin mentioned in the book mainly talks about the aetiology,that serve as a link between past and future in formation and development of toxin-Qi theory.