Research On Surgical Treatment Of Obstructive Sleep Apnea-hypopnea Syndrome And Change Of Serum Markers

Objective To treat obstructive sleep apnea-hypopnea syndrome (OSAHS) with one stage multilevel operation and evaluate treating effect. Methods One hundred and ninety patients of OSAHS (who have at least 2 obstruction levels) were treat with tongue coblation+uvulopalatopharyngoplasty+hard palate shortening+Repose suspension. The length of follow up was 6 months and complete data of 81 patients was collected. Apnea hypopnea index (AHI), lowest oxygen percent saturation (LSaO2), body mass index (BMI), vallecula epiglottica-lateral pharyngeal wall (V-LPW) and pharyngeal airway space (PAS) was used for diagnosis and evaluation. Results The LSaO2 of 81 patients increased from (0.71±0.01) to (0.82±0.07) (x±s),t=18.32.11.04, P＜0.01.The AHI reduced from (0.632±0.007) to (0.794±0.006),t=4.1, P=0.000. The V-LPW increased from (12.1±3.2) mm to (16.9±2.6) mm (t=2.5, P=0.014). PAS increased from (9.2±3.3) mm to (15.6±2.4) mm (t=7.6, P=0.000). The total effective rate is 74.1%. Conclusion one stage multilevel operation is an effective method of safety, simplicity. Objective To treat obstructive sleep apnea-hypopnea syndrome(OSAHS) with one stage multilevel operation and evaluate the consistency change in angiotensin II, AngⅡ, neopterin, resistin, S100β. Methods Thirty patients of OSAHS were treat with tongue coblation+uvulopalatopharyngoplasty+hard palate shortening+Repose suspension. The serum of the the patients and normal people were taken before opration and 6 months later. ELISA was taken to evaluate the consistency change in angiotensin II, AngⅡ, neopterin, resistin, S100β. Results 1. AngⅡwas related with the LSaO2, systolic pressure, AHI.The Npt increased with AHI. Resistin increased with the BMI.2.The level of angiotensinⅡ, AngⅡ, neopterin, resistin, S100βin OSAHS patients were higher than control group (P＜0.05).3. The level of angiotensin II, AngⅡ, neopterin, resistin, S100βdecreased after opration (P<0.05).Conclusion 1. The systolic pressure decreased with Ang II level after one stage multilevel operation. AngⅡmight related with the change of the BP.2. NPT was related with the svere of OSAHS and might be used to evaluate the svere of OSAHS and the therapeutic effectiveness of the operation.