| PurposeAnkylosing spondylitis (AS) is a major violation of axial joints systemic, chronic, inflammatory disease, often leading to ankylosis of spinal deformity. Because the cause of AS is unknown, the current lack of specific treatment western medicine, Traditional Chinese Medicine (TCM) treatment of the disease showed a unique effect. However, the lack of a unified domestic Chinese AS disease name, classification, staging and treatment evaluation criteria, etc., to the medical treatment of the disease or the further development of a breakthrough to bring some difficulties. This study aimed to summary and carry forward the heritage of old TCM expert Yan Xiaoping Professor of rheumatology academic thinking and treatment of AS of the academic experience, digging out the treatment of AS with significant clinical efficacy of the prescription for the study and play the TCM treatment the advantages of this disease has laid the clinical and theoretical basis is important.MethodThis study used a literature review, academic thinking and clinical experience, clinical research in three parts, organize and research the Professor Yan Xiaoping of rheumatology academic thinking and the treatment of AS academic experience. The methods used in the literature review section is a summary and analysis of academic Ideological Origins of Professor Yan Xiaoping of AS, schools and physicians point of view. Methods used in academic thinking and clinical experience part is to summarize and organize Professor Yan Xiaoping of rheumatology academic thought and clinical experience, academic experience of AS. Controlled clinical study in the clinical research section, the treatment group were received Bushen Qiangdu Recipe of Professor Yan Xiaoping treating502cases of AS patients, and the control group using the Bushen Qiangdu Recipe +Sulfasalazine(SASP) treatment of36cases of AS patients. The clinical study analyzed the clinical features of AS patients of the treatment group, also observed the two groups of patients with clinical symptoms, signs and disease activity index before and after treatment. This study analyzed the drugs commonly used features of Professor Yan treatment of AS. In this study, expectations Bushen Qiangdu Recipe on the clinical treatment of AS patients, summarizing and refining the treatment of AS the basis of party, to lay the foundation for the Chinese Medicine treatment of this disease.ResultIn order to organize and study Professor Yan Xiaoping of rheumatology academic thought and clinical experience, the system summary and refining division Professor Yan emphasis on rheumatic cold and heat as the key link, advocating of cold and thermal drug use; focus on primary and secondary symptoms and signs of rheumatology, advocacy treatment of the primary and secondary symptoms simultaneously; stressed that treatment based on the differential diagnosis, refining the rule and common prescription; rheumatology diagnosis and treatment highlight comprehensive analysis of the data gained by the four methods of diagnosis, emphasis on tongue diagnosis and pulse diagnosis; familiar with TCM classic, stressed that the treatment of disease as the first; great importance to TCM clinical research study both Chinese and western medicine. By finishing with the study of Yan Professor ankylosing spondylitis academic experience, Summary and analysis put forward by Professor Yan TCM diseases, pathogenesis, syndrome type theoretical system, treating law, the "five comic" therapy. Professor Yan in1999with help of their mentor, Professor Jiao Shude teach American graduate thesis formally proposed:AS related to TCM disease name-the "dyphosi s." The major cause of morbidity dyphosis pathogenesis is due to the results of two inside and outside, internal factors are the Governor kidney deficiency, yang deficiency, external factors are mainly wind cold dampness evil (especially those cold dampness emphasis) deep invasion of the kidney Governor. Professor Yan claims in accordance with her mentor, Professor Jiao Shude, in inherited Jiaoshu De Professor dyphosis four types(Kidney Governor cold syndrome, Evil stagnated-heat syndrome, Blockage of the limbs syndrome, Evil invade liver and lung syndrome) on the basis, combined with her long-term valuable clinical experience in diagnosis and treatment of patients with AS have accumulated a lot of the dialectic of this disease is divided into exacerbation and remission of the two six syndrome type, the exacerbation of kidney Governor cold syndrome, Evil stagnated-heat syndrome, Hot and humid injured kidney syndrome, Evil paralysis limbs syndrome, Evil invade liver and lung syndrome, and remission of mitigation and stability syndrome, forming a complete theory of dyphosis syndrome type system. And then to cold and heat as the key link, Professor Yan sum up the kidney Governor cold syndrome, kidney damp-heat two syndromes, and has been incorporated into the State Administration of Traditional Chinese Medicine,"Eleventh Five-Year" key specialist rheumatology-dyphosis (AS) national clinical trial program. She’s "Invigorating the Kidney and Strengthening Bone","Activating Blood Circulation to Dredge Channels","Regulating Ying and Wei","Through by the dialectical","Regulating the Function of the Liver and spleen" and other laws in the diagnosis and treatment of AS have achieved a better treatment efficacy. The study was also the first system to summarize and innovative diagnosis and treatment of the name of the other two rules-Conditioning lung, Regulating heart to treat Bi. Conditioning lung method mainly refers to the treatment of lung associated with a variety of broad and general treatment method, including nourishing Yin, nourishing lung, promoting the dispersing function of the lung, clearing away heat of lung, clearing away heat and eliminating dampness, and other rules; Regulating heart to treat Bi method, including invigorating Qi and nourishing heart, clearing away damp-heat, clearing away the heart-fire and removing toxic material, nourishing the heart to calm the mind, activating blood circulation to dredge channels, and so on.The clinical studies by using the Bushen Qiangdu Recipe of Professor Yan to treat AS patients have shown, AS patients with the ratio between men and women is about4.64:1, age of onset between the ages of15to34(387cases,77.09%), average age of onset (24.51±7.83) years, of which16.14%(81cases) patients have a family history of AS,92.03%(462cases) in patients with HLA-B27positive examination. This is the current domestic and international knowledge and research reports are basically the same. Because AS can lead to secondary generalized osteoporosis, has attracted wide attention at home and abroad physicians, this study examined the use of DEXA method over the age of20to496AS patients lumbar spine, femoral bone mineral density, bone findings osteoporosis, bone mass to reduce the total incidence rate of70.77%, suggesting that the prevalence of AS in patients with reduced bone density, further research and study for the prevention and treatment of TCM to lay a certain AS osteoporosis clinical basis. Professor Yan treatment of AS drugs commonly used features of analysis results, the potency prompted she like cold medicine together with the temperature drug use, drug classification of the top three for the antirheumatics,drugs for promoting blood circulation and removing blood stasis, drugs for kidney-tonifying, according to meridian tropi sm of the top three in the liver, kidney, spleen. Above Treating law commonly used in drug analysis results and proposed by Professor Yan is consistent. In addition,502patients with AS in patients with kidney deficiency syndromes mainly Governor cold syndrome, blood stasis dominated, accounting for96.81%of all patients with AS, 98.21%, also corroborated the above-mentioned law of dyphosis necessity and importance of treatment of the rule. Through by using Bushen Qiangdu Recipe, AS patients with ESR and CRP decreased significantly compared with before treatment, BASFI, BASDAI and other related index also improved significantly, confirmed the Bushen Qiangdu Recipe can reduce the immune and inflammatory response in patients with AS, to inhibit bone resorption in patients with immune and inflammatory effects of AS. Therefore, the Bushen Qiangdu Recipe can regulate immune function, fight osteoporosis, is the basic prescription of AS. And long-term using Bushen Qiangdu Recipe is safety, non-toxic side effects.ConclusionSummary the Professor Yan diagnosis and treatment of rheumatism great importance to the cold and heat as the key link, focus on primary and secondary symptoms and signs of rheumatology, stressed that treatment based on the differential diagnosis, rheumatology diagnosis and treatment highlight comprehensive analysis of the data gained by the four methods of diagnosis, familiar with TCM classic, stressed that the treatment of disease as the first, great importance to TCM clinical research study both Chinese and western medicine. AS related to TCM disease name is the "dyphosis." Its etiology and pathogenesis are the Governor kidney deficiency, yang deficiency, wind cold dampness evil (especially those cold dampness emphasis) deep invasion of the kidney Governor. There has formed a complete theory of dyphosis syndrome type system."Invigorating the Kidney and Strengthening Bone","Activating Blood Circulation to Dredge Channels","Regulating Ying and Wei","Through by the Dialectical","Regulating the Function of the Liver and Spleen" and other laws have achieved good results in the diagnosis and treatment of AS. The study was also the first system to summarize and innovative diagnosis and treatment of the name of the other two rules-Conditioning lung, Regulating heart to treat Bi. Through the use of "Bushen Qiangdu Recipe" can reduce in patients with ESR, CRP, improve the patient’s BASFI, BASDAI and other related indices, reduce the immune and inflammatory response in AS patients, by regulating the immune function to fight osteoporosis, long-term use safety, non-toxic side effects. |
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