Association Between MicroRNA Related SNP And Genetic Susceptibility Of PTC: A Case-control Study In Chinese Population

Objective:The aim of this study was to evaluate roles that rs2910164played in genetic predisposition of PTC in BN cases as well as cancer-free controls in a Chinese sample set and to estimate association between this miR-SNP and clinical characteristics in pathologically confirmed PTC patients.Design, Setting and Patients:We genotyped rs2910164in753PTCs,485BNs and760controls in a Chinese Han population. Clinical information was collected completely in all cases.96PTC cases with para-cancer BN confirmed by histologically were found and conversions from BN to PTC were proposed happened in those patients. Multivariate logistic regression was performed to calculate adjusted odds ratios (ORs) and95%confidence intervals (CIs).Results:There were no differences of rs2910164genotype distributions between those three groups. Patients with para-cancer BN had elder age, smaller cancer lesions, lower serum TSH levels and lower rates of lymph node metastasis. A multivariate logistic regression analysis showed that GG homozygote of rs2910164(OR=0.010,95%CI1.22-4.14) was the only independent risk factors for malignant conversion in patients with benign tumors, whereas age, gender, serum TSH level and Hashimoto thyroiditis were not associated with this process.Conclusion:Rs2910164was not associated with risk of PTC, but may play a role in the transformation from BN to PTC lesions. More validation populations and experimental evidence are needed in future studies.