Numerical Simulation Of Cerebrovascular Disease

Background: Cerebrovascular disease in middle age and old ageChinese is a common and occurring disease, on the rise in recent years andyounger age trend,with high morbidity, mortality and disability, has becomea major public health problem. For its etiology, pathogenesis, clinicalmanifestations, diagnosis, differential diagnosis, treatment and prognosis,Clinical Medicine has been more profound understanding in the past. But itshydrodynamic characteristics of local cerebral vascular is not yet a clearunderstanding, which influences doctors to make deeper judgments on thediagnosis and treatment of these diseases.CFD by accurately calculation cansimulate the hydrodynamic characteristics of cerebral vascular withintuitive images,providing great help to doctors in-depth understanding ofcerebral blood flow. However,due to its multi-disciplinary nature, it wasrarely used clinically and was more less applied to the research ofcerebrovascular disease and cerebrovascular disease intervention.Objective: To study methods of modeling of cerebrovascular diseaseand carry out numerical simulation. To raise awareness of this disease.Methods: A total of100elderly patients with suspectedcerebrovascular disease were randomly selected for invasive cerebral vascular pressure monitoring during the digital subtraction angiography.Curves were function-fitted using MATLAB7.0, all functions werestandardized to derive one representative function. To validate this functionmodel,50patients were randomly selected additionally. A patient (female,67years old) with left internal carotid artery spiral giant fusiform aneurysmwere selected during the digital subtraction angiography, the relevant datawas obtained simultaneously. Postoperatively in combination withMIMICS12.0,Geomagic Studio12and UGS NX8.0, fluid-structureinteraction model was built, and compared with traditional modelingmethods,then obtained reliable methods of fluid-structure interactionmodeling of cerebral vascular.And then a patient with multiple tandemartery aneurysms in left internal carotid artery and a successful case ofcerebral embolism by Penumbra mechanical thrombectomy were selected tocarry out finite element modeling using representative function and the newmodeling approach. Numerical simulation study was carried out usingANSYS14.0.Results: Had built an extensively representative function model forcerebral vascular pressure.In an example of complex intracranialaneurysms,obtained a reliable modeling method of cerebral vascularfluid-structure interaction model, numerical simulation of tandem leftintracranial internal carotid artery aneurysms and the case of cerebralembolism by Penumbra mechanical thrombectomy had got satisfactory results.Conclusions: In combination with MATLAB7.0,MIMICS12.0,Geomagic Studio12, UGS NX8.0and ANSYS14.0, numerical simulationof common cerebrovascular disease will be well carried out,which can helpphysicians involved in a clearer understanding of hydrodynamiccharacteristics of cerebral vascular of patients. As a research method,it isworth to continue to explore in the future.