| Objective:1. To observe the sublingual veins of patients with coronary heart disease by coronary angiography or computed tomography (CT) with clear relationship between the pathological changes of the blood vessels, observe tongue collaterals the coronary heart disease (CHD) patients with different diseases and coronary heart disease (CHD) Huizhuotanzu syndrome and the sublingual collaterals in patients with non-Huizhuotanzu syndrome, so as to analyze coronary lesions associated with whether the sublingual veins, different cases of coronary heart disease patients with sublingual veins, to study the tongue diagnosis in traditional Chinese medicine clinical data accumulation, in order to further study tongue veins and vascular disease.2. By evidence-based medicine, on postoperative patients with coronary reascularization choice in line with the type of proprietary Chinese medicine, to observe the curative effect of combination of traditional and western medicine to observe the TCM symptom score, blood stasis syndrome scoring scale, Seattle, end index, the difference of adverse reaction and safety evaluation, observation time is1year, research the curative effect of TCM intervention after coronary reascularization.3. According to the characteristics of atherosclerosis in xinjiang, dry and cold climate environment simulated high cholesterol diet characteristics and preparation of atherosclerosis dirty phlegm syndrome animal model, in order to pass the animal experiment research for the future dirty phlegm syndrome.. Methods:1. June to2013years in October2013, the autonomous region hospital patients with coronary heart disease in hospital and clinic, collection like the tongue, and observe its tongue length, thickness, color and circuity, etc., and compared with healthy controls.2. October2011years-in the autonomous region hospital in October2012and autonomous region people’s hospital of selection by coronary angiography diagnosis concurrent coronary artery stent implantation of coronary artery disease in hospitalized patients, divided into the treatment group and control group, treatment group on the basis of conventional western medicine therapy intervention of Chinese medicine, the control group only by western medicine routine treatment, in the group before and after1month,3months,6months,12months follow-up for time point, follow-up time is one year, observe two groups of patients in the TCM symptom score, blood stasis syndrome scoring scale, Seattle, end index, adverse reaction and safety evaluation of differences.3. Will be60apoe knockout mice were randomly divided into four groups, namely high fat feedstuff and dry cold environment joint intervention model group, high fat feed simulation of xinjiang residents diet control group, in the simulation of the dry and cold environment of xinjiang climate control and feed at room temperature to the ordinary feed the blank control group. Applying cold dry environment and high cholesterol groups of mice were feed related intervention. To12weeks to observe and record the mice body weight, feeding behavior, such as urine, upper arm tolerance, tongue like biological characterization; Blood was taken from the death and detecting blood lipids and other biochemical indicators; Optical microscopy mice cell morphological changes of aortic specimens. After the related indices are compared between groups.Results:1. The selected patients157cases, with80cases of coronary heart disease group, the male52cases,28cases of women, aged between30-75, the average age of56,77cases of healthy control group45cases of men, women,32cases, aged between30-75, the average age of54, in coronary heart disease group Huizhuotanzu syndrome in49cases, non-Huizhuotanzu syndrome obstruction31cases. Patients with coronary heart disease group and health control group comparison, in the context of the tongue length, thickness, color, circuity level differences were statistically significant (P<0.01),coronary heart disease (CHD) dirty phlegm syndrome group compared with the dirty phlegm resistance syndrome group, in the context differences of length, degree of circuity tongue no statistical significance (P>0.05), in terms of the thickness, color tongue veins difference was statistically significant (P<0.01), pure tongue veins of coronary heart disease patients with short, thin, blue, mild circuity as the main performance, coronary heart disease patients with diabetes mellitus in tongue veins with a long, thick, bruising, severe circuity as the main performance, amalgamating hypertension coronary heart disease (CHD) patients with tongue vein length, thickness and circuity degree is given priority to with moderate, colour is given priority to with blue, coronary heart disease, diabetes mellitus and hypertension patients with tongue veins is given priority to with long, thick, bruising, severe circuity. Coronary heart disease (CHD) count different coronary lesions and tongue veins probability level in terms of length of the significance of the correlation coefficient is less than0.001, there is a clear correlation, according to the relationship of level value plus or minus, the lesion count is negatively related to the long range, tip: coronary artery lesion count, the more the longer the tongue veins, the shorter the conversely. Count different coronary lesions and tongue veins correlation coefficient on the thickness of significant at0.291probability level, without obvious correlation. Count different coronary lesions and tongue veins in the aspect of color correlation coefficient of the probability of significance level is less than0.001, there is a clear correlation, according to the r value plus or minus, the lesion counts, associated with the color shades: the more coronary lesion counts, tongue veins the deeper the color, the lighter conversely. Count different coronary lesions and tongue veins in circuity level correlation coefficient of the probability of significance level is less than0.001, there is a clear correlation, according to the r value plus or minus, in direct proportion to the degree of lesion counts and circuity, tip:the more coronary lesion counts, tongue veins circuity level is heavier, the lighter conversely.2. Selected326cases of patients with total, complete test cases301cases, fall off25cases, the loss rate was8.3%, among them from moving abroad to study3cases,17were lost to follow-up, poor adherence to its exit research in5cases. Experimental group157cases, control group157cases,144cases,223cases of male, female68cases. Experimental group compared with the control group before and after treatment of blood stasis syndrome score difference obvious, with statistical significance (P<0.01), the experimental group was significantly lower score, in the aspect of TCM symptom score, score group called the control group decreased significantly, the difference was statistically significant (P<0.01), the SA Q scale including limited physical activity level (PL)(AS), stable angina, angina frequency (AF), treatment satisfaction (TS) and subjective (DP) and so on five subgroups19investigation and quantitative analysis tools by the statistical results show that the intervention of traditional Chinese medicine can effectively improve angina attack situation, compared with the control group was statistically significant difference (P<0.01), treatment group and control group before and after treatment electrocardiogram change difference was not statistically significant (P>0.05), the experimental group compared with control group end point events difference was statistically significant (P<0.05), by the statistical results show that the experimental group and control group before and after treatment in the WBC, RBC, PLT, ALT, AST, BUN, Cr, coagulation indexes of four comparison difference has no statistical significance (P>0.05), treatment group and control group in the treatment has not been before and after the occurrence of adverse events and adverse reactions.3. After observation analysis, joint intervention high-fat feed cold and dry environment dirty experimental mice is a reflection of the phlegm syndrome characterized the most outstanding, light microscope to observe the aorta cells form, the type arteries can be observed in atheromatous plaque and intimal thickening, after high cholesterol feeds and dry cold environment on the role of the lining/lumen ratio analysis, two kinds of interference factors on the lining/lumen ratio alone effect and the influence of the interaction was statistically significant difference (P<0.05); That high-fat feed cold and dry environment has promoting effect to the intimal thickening, make the lining/lumen ratio increased, while two factors combined intervention of atherosclerosis model group mice is more outstanding, high cholesterol feed, and cold dry environment of ApoE knockout mice blood fat rise no significant role in promoting.Conclusion:1. Coronary lesions and the length of the tongue veins, degree of thickness, color, give all have certain relevance, and according to the different TCM syndrome types, merge disease and coronary artery lesion count of different, its tongue all have different degrees of difference. After2. Blood supply reconstruction using the cooperation of Chinese and western medicine treatment of TCM plus western medicine is better than pure western medicine treatment can effectively improve the degree of postoperative patients with blood stasis, reduce the frequency of angina pectoris was to improve the quality of life of patients, reduce the incidence of postoperative restenosis and cardiovascular adverse events.3. Residents in xinjiang high cholesterol diet composite simulation cold dry climate environment of xinjiang atherosclerosis Huizhuotanzu syndrome method is feasible, can be successfully established with atherosclerosis Huizhuotanzu syndrome obstruction the biological characterization and part of the biological basis of similar model combined disease, building success. |
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