Research On Secondary Prevention Strategies Of Cerebral Infarction Of Recovery Phase Based On The Constitution-disease Related Theories

Objective: To explore secondary prevention strategies of Cerebral Infarction of recovery phase based on the constitution-disease related theories.Methods: According to the "Chinese constitution classification and decision tables(ZYYXH / T157-2009)" promulgated by China Association for Traditional Chinese Medicine, to judg gentleness status, Qi deficiency status, yang deficiency status, yin deficiency status, phlegm status, damp heat status, blood stasis status, Qi Yu status and special status. Using epidemiological methods, investigate Cerebral Infarction patients of recovery phase in Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Weifang Hospital of TCM, Tai’an Hospital of TCM, Weihai Hospital of TCM, Penglai Hospital of TCM, Rencheng Hospital of TCM and other six hospitals of different levels and different regions. To determine physical status and to record risk factors(gender, age, race, hypertension, diabetes, heart disease, hyperlipidemia, smoking, drinking, WHR, lack of physical activity,habit). ① a formal questionnaire was formed after the pre-survey. Included 403 cases, including Cerebral Infarction patients of recovery phase of various status, to analyze various status’ regularities of distribution; ② To clarify risk factors of Qi deficiency status and phlegm status which were the first two of the frequency, 339 cases of Qi deficiency status and 349 cases of phlegm status were investigated, with 102 cases of gentleness status as control. Logistic regression analysis was used; ③ There were 149 and 102 prescribing information of Qi deficiency status and phlegm status respectively. After data cleaning association rules analysis, set the minimum support of 20%, the minimum confidence level of 100%.Results: ① investigate 403 cases of Cerebral Infarction patients of recovery phase, status frequency were: Qi deficiency status(89 cases, 22.08%), phlegm status(87 cases, 21.59%), blood stasis status(58 cases, 14.39%), yin deficiency status(56 cases, 13.90%), Qi Yu status(32 cases, 7.94%), gentleness status(31 cases, 7.69%), yang deficiency status(24 cases, 5.96%), damp heat status(21 cases, 5.21 %) and special status(5 cases, 1.24%). Physical status distribution has a significant difference(P <0.05) in gender, age, occupation, work intensity, type of obesity, sleep,exercise, smoking, eating greasy fatness and taste salty, and no significant difference(P> 0.05) in alcohol and eating spicy.② by logistic regression analysis, male, poor sleep, staying up late are risk factors of Qi deficiency status, exercise is a protective factor of Qi deficiency status; central obesity, sleep in general, stay up late, eat greasy fatness are risk factors of phlegm status, work intensity and exercise are protective factors. Compared with gentleness status, Qi deficiency status and phlegm status had no difference in history of the diseases.③Qi deficiency status of Cerebral Infarction of recovery phase most commonly used astragalus, angelica root, Codonopsis, Poria, red peony, peach, Atractylodes, licorice, yam; main drug couple is Poria- Licorice combination; a similar combination of commonly used drugs is Buyanghuanwu soup and according to the situation plus Cistanche, Tianma, Guizhi, Radix and other. phlegm status of Cerebral Infarction of recovery phase most commonly used drugs are Breit, licorice, orange peel, root, Poria, Codonopsis, Zhuru, Atractylodes, citrus aurantium, Angelica; main drug couple include turmeric-Zhuru, Citrus- turmeric, Tianzhu Huang- Zhuru, Citrus- Alisma; common pharmaceutical compositions summarized as Erchentang, Wendantang, Daotantang or Ditantang, and according to the situation plus drug for invigorating blood circulation and eliminating stasis(turmeric, peach, safflower, angelica root), Shichangpu, Alisma,Rhizoma Cyperi and so on.CONCLUSION: Secondary prevention strategies of Cerebral Infarction of recovery phase can be summarized as " prevention and treatment based on status judgment and risk factors screening". Based on physical status, using drugs and lifestyle changes to adjust status bias, reducing the formation of pathological factors, to prevent the recurrence of cerebral infarction, reaching the purposes of " treatment before being sick".