Growth Differentiation Factor-15Genotype And Plasma Level:Associations With Coronary Artery Disease

BackgroundGDF-15is a member of the TGF-β cytokine superfamily. It is induced by various forms of stress, such as inflammation, oxidative stress, ischemia-reperfusion injury and so on. Many studies suggest that a large amount of GDF-15is secreted to resist apoptosis during the acute phase of cardiovascular disease, and high level of GDF-15is associated with severity of the disease and poor prognosis. Single Nucleotide Polymorphisms (SNP) of GDF-15are found to be associated with the bioactivity of this protein, and that means genotypes may play an important role in GDF-15-related phenomenons. GDF-15plasma level and genotypes may provide diagnostic and prognostic information in patients with coronary artery disease.MethodsBlood samples were obtained after CAG from264patients with chest uncomfortable. GDF-15genotypes were determined by direct sequencing method. Clinical and biochemical information was recorded and all patients were followed up.Resultrs1059519:Genotype CC group have a higher risk of ACS and CAE, P=0.045. The three clinic groups have different frequencies of allele C, P=0.017. The genotypes are associated with GDF-15plasma level. In genotype CC group, GDF-15<400ng/L is associated with poor prognosis and in genotype CG group, GDF-15>1000ng/L is associated with bad prognosis, P=0.022.rs1059369:Genotype AA group have a higher risk of ACS and CAE, P=0.017. The three clinic groups have different frequencies of allele A, P=0.008. No three SNPs are associated with the poor prognosis and PCI benefit.ConclusionsGDF-15genotypes are associated with severity of coronary artery disease significantly and GDF-15plasma level is associated with severity of coronary artery disease and poor prognosis significantly only after remove the confounding effect of genotypes.