Clinical Study On Xuanfei Tongqiao Method In The Treatment Of Asthma-slow-resistance Pulmonary Overlap Syndrome

Objective:To evaluate the clinical efficacy of "dispersing lung-qi and moving the faeces" in treatment of asthma COPD overlap syndrome,it will provide the theoretical foundation and the clinical demonstration for Jiawei Xuanbai Chengqi tang treating patients with ACOS.Methods:Mufti-center,randomized and controlled trial was designed.88 patients who got ACOS were randomly divided into treatment or control group.The patients from control group were western medicine treatment, which course was 7 days.In addition to the above treatment,the patients from treatment group were Jiawei Xuanbai Chengqi tang, which 100ml/time,3 times a day,7 days a course.We observe changement of the total score of symptoms and signs,pulmonary function(FEV1/FVC, FEV1%pre,PEF%pre),arterial blood gas(PaO2,PaCO2,PaO2/FiO2,lactic acid)and frequence of ACOS breaking out,FeNO,IgE,EOS,NEU% after 3 days and 7 days respectively.By which,wecompare the clinical efficacy of treatment group and the control group,neutrophil percentage change of the equivalent, in 3 days,7 days.Results:1、Comparison of efficacy between two groups:14 cases were heald,17 cases were markedly effective,8 cases were effective and 4 cases had no effect in the treatment group,the total effective rate was 90.70%, control and excellent effect rate was 72.09%.With the corresponding, the control group effect were respectively 8,13,15,7.The total effective rate was 83.72%,control and excellent effect rate was 48.84%.They have statistically significant difference(P<0.05),the treatment group is better than the control group.2、Comparison of the total score of symptoms and signs between two groups: no statistically significant difference (P<0.05),the treatment group is better than the control group.3、Comparison of pulmonary function between two groups:no statistically significant difference in FEV1/FVC(P>0.05).There was statistically significant difference in FEV1%pre,(P<0.05),the treatment group is better than the control group.There was statistically significant difference in PEF%pre(P<0.05),the treatment group is better than the control group.4、Comparison of arterial blood gasbetween two groups:no statistically significant difference in PaO2(P>0.05).There was statistically significant difference in PaCO2(P<0.05),the treatment group is better than the control group.There was statistically significant difference in PaO2/FiO2(P<0.05),the treatment group is better than the control group.There was no statistically significant difference in lactic acid(P >0.05).5、Comparison of frequence of ACOS breaking out between two groups:no statistically significant difference(P<0.05),the treatment group is better than the control group.6、here was no statistically significant difference in FeNO between two groups (P>0.05).7、There was no statistically significant difference in IgE between two groups (P>0.05).8、Comparison of blood index between two groups:no both statistically significant difference in EOS,NEU%(P>0.05).Conclusions:Two treatments can both effectively cure ACOS.The clinical efficacy of the method of "dispersing lung-qi and moving the faeces"combining with western medicine for patients with ACOS is bettet than western medicine treatment.Jiawei Xuanbai Chengqi tang is safe and effective for patients with ACOS.