A Randomized Controlled Study Of TCM Psychosomatic Therapy For The Treatment Of MPS With Moderate-severe Mood Disorders

ObjectiveComplexity of physical symptom and repeation of emotional symptoms with PMS mood disorders affect the quality of life of the perimenopausal women.The requirement of life quality is much higher for modern women.The effect of hormones and antidepressant treatment is not obvious.It is necessary to long-term use,and dependence.At the same time,there is no definite effective and practical scheme of psychosomatic development of traditional Chinese medicine treatment of perimenopausal syndrome mood disorders.It is important to explore TCM psychosomatic therapy for PMS mood disorders.The result of our initial clinical research is that the effect of TCM psychosomatic therapy is confirmed for PMS mood disorders,but for the patients with moderately severe mood disorders,there is no obvious advantage by TCM psychosomatic therapy.Basing on the previous studies,some improvement are made according to the TCM psychosomatic therapy for further clinical research.Through observing the effect of TCM psychosomatic therapy for PMS mood disorders’ patients with renal deficiency and hepatic stagnation,to evaluate the clinical curative effect and safety of TCM psychosomatic therapy.MethodsCollect MPS with Moderate-severe Mood disorders’ patients from February 2016 to January 2017 in the guangdong hospital department of gynaecology.Patients are ruled out severe mental illness by the psychological doctor.There are 85 patients with kidney liver depression type.According to random number table they are divided into Chinese medicine group and TCM psychosomatic group.TCM group is taken with kidney and liver grain,TCM psychosomatic group accept kidney and liver grain and psychological treatment.The treatment cycle is eight weeks,and follow-up period is 4 weeks for for each group.The curative effect index of the clinical study are Greene(standard greene climacteric scale),CMRS(TCM standard for climacteric scale)and SDS(self-rating depression scale),SAS(self-rating anxiety scale).security index are blood and urine routine examination,liver and kidney function test,electrocardiogram,gynaecologic ultrasound.Comparing the difference between treatment and follow-up point for efficacy index.security and compliance are evaluated after treatment.What’ s more,adverse reactions and events for each group are included during treatment.This research adopts full analysis set information.Results1.The score of Greene,CMRS,SDS and SAS in every point is much lower than prior treatment both Chinese medicine group and TCM psychosomatic group.There is significant difference(P<0.05).It shows that both Chinese medicine therapy and TCM psychosomatic therapy can improve somatic and mental symptoms for PMS patients in every point.2.There is no difference about the score of Greene,CMRS,SDS and SAS between Chinese medicine and TCM psychosomatic group in fourth week(P>0.05).It shows that there is no difference of clinical effect both groups.What’s more,It shows that there is no obvious advantage in a short treatment time for TCM obvious advantage.3.In 8th and 12th week,the score of Greene,CMRS,SDS and SAS of TCM psy chosomatic group is lower than Chinese therapy’s.There is statistical sig nificance(R<0.05).The score of TCM psychosomatic group before and after t reatment is lower than Chinese therapy’s.There is statistical significanc e(P<0.05).It is that clinic effect of TCM psychosomatic therapy is bette r than Chinese therapy’ s In 8th and 12th week.4.By repetitive measure analysis of variance in every observation point,scores of Greene、CMRS、SDS and SAS are influenced by time,group,time and group interaction.Scores of Greene、CMRS、SDS and SAS change with time,gro up,time and group interaction.5.By repetitive measure analysis of variance for Greene in every observation point,anxiety and depression dimension are influenced by time,group,time and group interaction.Physical dimension are influenced by time,time and group interaction.Vasomotor dimension is influenced by time,rather than group,time and group interaction.Sex dimension aren’ t influenced by time,group,time and group interaction.6.By repetitive measure analysis of variance for CMRS in every observati on point,each dimension is influenced by time,group,time and group intera ction.7.By repetitive measure analysis of variance for SDS in every observatio n point,anxiety-depression dimension are influenced by time,group,time an d group interaction.Lose of self dimension are influenced by time,time an d group interaction,rather than group.Motive power dimension is only infl uenced by time,rather than group,time and group interaction.Physiology di mension is also only influenced by time,rather than group,time and group interaction.8.By repetitive measure analysis of variance for SAS in every observation point,anxiety dimension are influenced by time,time and group interactio n,rather than group.Autonomic nerve dysfunction dimension are influenced by time,group,rather than time and group interaction.Physical and move d imension are influenced by time,rather than time and group interaction.9.Moderate mood disorders:There is no difference about the score of Gre ene,CMRS,SDS and SAS between Chinese medicine and TCM psychosomatic group in fourth week(P>0.05).It shows that there is no obvious advantage in a short treatment time for TCM obvious advantage.In 8th and 12th week,the score of Greene,CMRS,SDS and SAS of TCM psychosomatic group is lower th an Chinese therapy’ s.There is statistical significance(P<0.05).It is that clinic effect of TCM psychosomatic therapy is better than Chinese therap y’s in 8th and 12th week.Each node compared with before treatment,there i s differences in Greene,CMRS,SDS,but not in SAS,it shows that TCM psyc hosomatic therapy is good at improving scores of Greene,CMRS,SDS,rathe r than in score of SAS.10.Severe mood disorders:There is no difference between Chinese group an d TCM psychosomatic group in each observation point(P>0.05).There is no difference between before and after treatment in both groups(P>0.05).TCM psychosomatic therapy is not better than Chinese medicine treatment.11.Single amine neurotransmitter:the DA and NA content in all patients was increased after treatment.It is significant between before and after-treatment in both groups(P<0.05),Chinese medicine treatment and TCM psychosomatic treatment can increase the DA and NA content in the body.There is no difference of DA and NA content between groups(P>0.05),it shows that there is no difference with Chinese medicine treatment and TCM psychosomatic treatment in increasing the content of DA and NA(P>0.05).Conclusion1.Both Chinese medicine and TCM psychosomatic therapy can obviously impr ove the perimenopausal syndrome of somatic symptoms and mood disorders.2.TCM psychosomatic therapy is beneficial to improve and maintain perime nopausal syndrome patients with moderate and severe mood disorders.3.TCM psychosomatic therapy can significantly improve the clinical sympt oms of menopause syndrome and depressive symptoms in patients.But there i s no advantage in improving anxiety symptoms.The clinic effect for moder ate mood disorder is better than severe mood disorder with TCM psychosoma tic therapy.There is no obvious advantage for severe mood disorder.causes of that may be associated with less observed number of cases.It may need ed to explore prioritization scheme for severe mood disorders.4.The clinical efficacy of perimenopausal syndrome moderate-severe emoti onal disorders is correlation with time,so it requires both doctors and patients attache great importance to treatment course.The adherence of TCM psychosomatic therapy is better than Chinese treatment,but there is n o statistical significance in groups.It may highlight the adherence advan tages of psychosomatic development by enlarging sample.5.There is no difference in the content DA and NA between groups,it may be associated with less sample size.DA,NA content in TCM psychosomatic group was increased more than TCM group.if increasing the sample size it is likely to highlight the advantage of TCM psychosomatic treatment in improve single amine neurotransmitter.6.It is safe and reliable to Chinese medicine treatment and TCM psychoso matic therapy for PMS with moderate-severe mood disorders.It is worth fo r further clinical application.