| Persistent luminescent materials（PLMs）could emit light for a long time even after the stoppage of external excitation,which are widly applied in transportation,military,security,information storage,etc.In recent years,PLMs present significant application prospect in biomedical imaging,diagnosis and treatment,due to unique imaging characteristics without background-interference.As one of the deadliest diseases in the world,cancer is still a serious public health problem.Effective treatment of cancer is still a serious problem owing to the complexity,diversity,heterogeneity and easy metastasis of tumor.The commonly used clinical treatment methods,such as radiotherapy,chemotherapy and surgery,have their own limitations.In recent years,a number of emerging cancer treatments,such as photodynamic therapy,gas therapy and photothermal therapy,have achieved lots of attention.Compared with the traditional treatment,these new treatment have the advantages of less side effects,better therapeutic effect and better selectivity.However,there are still many problems in tumor treatment,such as low penetration depth of excitation light,hypoxia,monotherapy,long excitation time and so on.In order to overcome these difficulties,multifunctional Zn Ga2O4-based PLMs as nanocarriers were developed to study the problem of hypoxia,penetration depth,excitation time,multi-modal treatment.And the therapeutic effect of multifunctional Zn Ga2O4-based PLMs was evaluated.The main contents of this paper are as follows:（1）Zn Ga2O4:Mn（ZGO:Mn）PLMs were successfully synthesized by using hydrothermal method combined with sintering.The crystal phase,morphology and luminescence properties of ZGO:Mn PLMs were systematically studied by varing Mn2+doping concentration and sintering temperature.The results show that the afterglow performance of the PLMs could be adjusted by varing Mn2+doping concentration and sintering temperature.The PLMs present green afterglow emission（504nm）and lasted for 12 h after excited by X-ray.The repeated deep tissue afterglow imaging（24 mm）could be obtained,providing a new strategy for extending its biooptical imaging without background-interference.（2）A low-dose soft X-ray responsive ZGO:Mn-SiO2@RBS（ZGO:MN-RBS）nanoplatform for NO persistent release and gas treatment was firstly constructed by coating SiO2 on the surface of ZGO:Mn and then combining NO donor[NH4][Fe4S3（NO）7]（Roussin’s Black Salt,RBS）.Based on the fluorescence resonance energy transfer,the NO gas release excited by soft X-ray was systematically studied.And the deep tissue（24mm）NO persistent release triggered by soft X-ray was realized.The results of in vitro/vivo tumor therapy revealed that the nanoprobes possess excellent gas antitumor therapeutic effect under X-ray excitation.Thus,the designed soft X-ray activated ZGO:Mn-RBS presents a new category of NO-releasing system,and may spark new inspiration for developing high-performance deep-tissue gas-releasing system for tumor treatment with mitigated side effect by using the afterglow materials.（3）TheZGO:Mn@PDA@Mn O2（ZGO:Mn@Mn O2）nanocomposites were successfully developed.Soft X-ray responsive ZGO:Mn@Mn O2+RB nanoplatform was successfully designed for photodynamic treatment by loading Rose Bengal（RB）.Hypoxic in tumor microenvironment could be overcomed by the catalytic reaction of Mn O2.Soft X-ray-reponsived enhancecd photodynamic therapy could be realized.The results of in vitro/vivo tumor treatments reveal that the designed nanoplatform has excellent anti-tumor effect and good biosafety under the excitation of soft X-ray.Therefore,the constructed nanosystem provides a basis for enhanced photodynamic therapy of deep tissue tumors.（4）Based on ZGO:Mn@Mn O2,a photothermal/photodynamic/gas multi-modal tumor treatment platform（ZGO:Mn@Mn O2+ICG+RBS）was successfully designed by loading Indocyanine Green（ICG）and RBS.X-ray responsive NO release could be achieved.Under 808 nm laser excitation,this nanoplarform presents the generation of reactive oxygen speciesandhighphotothermalperformance.The photothermal/photodynamic/gas synergestic treatment of tumor was successfully reliazed,providing a new direction for the development of multifunctional synergistic therapy.（5）On the basis of green long afterglow,we further prepared Zn Ga2O4:Cr（ZGO:Cr）PLMs with near-infrared（708 nm）afterglow emission.Based on the ZGO:Cr@PDA@Mn O2（ZGO:Cr@Mn O2）nanocomposites,a chemotherapy/photodynamic synergistic tumor treatment platform was successfully constructed by loading Doxorubicin（DOX）and Zn Pc photosensitizer.ZGO:Cr PLMs possess long near-infrared afterglow after irradiated by soft X-ray.p H-responsive anti-tumor drug release and soft X-ray triggered reactive oxygen generation could be achieved.And chemotherapy/photodynamic synergistic treatment for tumor was successfully realized,which greatly improved the efficiency of cancer treatment. |
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