Serum Amyloid A Was Correlated With Osteonecrosis Of Femoral Head By Affecting Bone Metabolism

Serum amyloid A(SAA)is an acute phase protein that elevates under inflammatory circumstance.The serum level of SAA was associated with the progression of inflammation in numerous diseases.However,little attention was paid to the correlation between SAA and osteonecrosis of the femoral head(ONFH).In this study,SAA was found risen in the femoral head of osteonecrosis patients through proteomics analysis and further confirmed by ELISA.Furthermore,SAA was proven affecting bone metabolism in rats bone marrow-derived mesenchymal stem cells(rBMSCs).It facilitated the proliferation of rBMSCs whereas it suppressed the osteogenic differentiation of rBMSCs and accelerated the adipogenic differentiation of rBMSCs.Thus,we deem that SAA,which is a vital acute phase protein in inflammation,affected bone metabolis and plays an imperative role in the pathophysiological process of ONFH.