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An investigation into Ca-DNA conformation as a function of relative humidity

Posted on:2011-11-21Degree:Ph.DType:Dissertation
University:The University of ToledoCandidate:Smith, Megan SchwenkerFull Text:PDF
GTID:1441390002459880Subject:Physics
Abstract/Summary:
Raman spectroscopy experiments on CaDNA free-standing, highly-ordered wet-spun films containing various concentrations of CaCl2 show that CaDNA does not adopt the A conformation and reveals a maximum of DNA in the B conformation at 80% relative humidity. Swelling experiments on these same films give information as to the intermolecular spacing between molecules. Finally, a proof of principle measurement of the activation enthalpy of guanosine is also given.
Keywords/Search Tags:Conformation
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