The effects of overproduction of bovine growth hormone on the T cell receptor repertoire in mice

The effects of overproduction of bovine growth hormone (bGH) on the T-cell receptor (TCR) repertoire were analyzed using a bGH transgenic mouse model. Mice transgenic for bGH overproduce the hormone, grow larger than their non-transgenic littermate controls, mature faster than normal animals, and have reduced life spans. In the first part of this study, the percentage of splenic T cells, percentage of CD4 and CD8 T cells, and the frequency of use of variable region beta chain segments 8.1 and 8.2, the most commonly used gene segments in the TCR ;In the second part of this study, the diversity of V-D-J junctions of the ;Thus, major differences were seen between transgenic and normal mice in the percentage of splenic T cells and the expression of V...