Mirna Signatures In Diagnosis And Prognosis Of Cutaneous T Cell Lymphoma

Cutaneous T cell lymphoma(CTCL)can have clinical and histological features resembling benign inflammatory dermatosis(BID)and can be difficult to diagnose.Very limited biomarkers are available for CTCL prognosis.We aimed to identify microRNA(miR)signatures to facilitate diagnostic and prognostic evaluations of CTCL.A cross-platform miR microarray identified 10 miRs that were differentially expressed between CTCL and BID patients.Subsequent RT-PCR validation was used to generate a 5-miR based diagnosing classifier,which showed high diagnostic accuracy in CTCL(AUC=0.985 and 0.956 for training and testing set,respectively).Association between miR expressions and patient prognosis was studied.miR-155 and miR-200b were significantly associated with overall survival in CTCL patients,outperformed Ki-67.miR expressions were combined with Ki-67 to create a classifier for 5-year overall survival in CTCL patients.Our work provided miR signatures to facilitate CTCL diagnosis and prognosis with satisfying accuracy.