Research Of The Using Rules Of Aconitum Based On Toxicity-Efficacy-Syndrome Relevance

Objective:The article try to clarify the time node of differentiation application of Aconitum and the characteristics of toxicity and efficacy.By collecting and arranging Aconitum prescriptions to build database try to find the rules of aconitum drug to increase efficiency and reduce toxicity.It includes processing,dosage,usage,dosage form,compatible medicine,main treatment disease syndrome and so on,which can provide theoretical basis for clinical safe use of drugsMethods:The article adopts the methods of analytical method,comparative approach and generalizing and combing the literature and prescription materials of TCM to explore the toxic effect characteristics of aconitum and the related factors affecting the toxic effect.The article try to find the origin of the application of differentiation of Aconitum.Using data mining technology,through frequency statistics,clustering analysis and other methods can help to reveal the rule of Aconitum control method,the rule of diseases and syndromes of compatibility of drugs.Results:Firstly,The time node of differentiation of Aconitum was at least in the late Tang Dynasty,which predates the description of the herbs in the Song Dynasty and the clinical application.Secondly characteristics of the toxic effects of Aconitum include fast,open close,great heat,dispelling the wind cold,strong poison tight,good rise and sink,lead the report,direct to the sick place.The related factors affecting aconitum toxicity and efficacy include dosage form,processing,usage,dosage,disease syndrome,compatibility,etc.Thirdly.Aconitum can increase its effect by the combination of Xinwei drug to dispel evil,such with the the taste of spice drug to dispel wind and dampness,with the Xinwen drug to remove blood and relieve pain;combining with Xinxiang drug to increase the blood circulation;combining with Kuhan drug to treat carbuncle;combining with Xifeng drug to dispel wind;combining with Wenli drug to dispel the cold;combining with toxic drugs of poisoning.Aconitum can reduce the toxicity by sweet taste drug of the reducing toxicity;compounding invigorate Qi and invigorate Spleen drug to correct poison;combining with Suanlian drug to control the toxicity;combining with Ziyin drug in case of injury;combining with cold medicine to control heat poison.Fourthly.Aconitum carmichaeli Debx is the most frequent compatibility of drugs of the warm,dispelling cold and dampness,benefit,dispelling the spasm and wind,dispelling phlegm,promoting blood circulation and removing,such as Rougui,Fangfeng,Danggui,Tianma,Tian nanxing,Chuanxiong and so on.The main treatment conclude Biopathy,Stroke,Pain,Sore disease,Headache.The common Syndrome conclude the cold pain,deficiency,wind-cold dampness,phlegm and stasis,cold coagulation stagnation,etc.Aconitum kusnezoffii Reichb is most frequent compatibility of drugs of dispelling rheumatism,dispelling phlegm,promoting blood Circulation and removing blood,stop the wind and spasm,deficiency,warm,such as Qianghuo,Banxia,Ruxiang,Tianma,Gancao,Ganjiang,etc.The main treatment conclude the Sore disease,Biopathy,Pain,Orthopedics.The common Syndrome conclude the cold pain,wind-cold dampness,hot,cold poison syndrome,etcConclusion:Firstly,the efficacy and toxicity of Aconitum originate from it’s spiced and hot.Secondly,the main efficacy of Aconitum is expelling wind and removing damness,warm menstruation to relieve pain.The poisoning mechanism is injury,negative consumption,abortion.Aconitum kusnezoffii Reichb is more potent and toxic.The toxicity of Aconitum carmichaeli Debx is slow and have the function of warming up.Thirdly,Aconitum was often used as processed products in the past.The multi-compatibility of Aconitum is combined with the pungent warm drugs and liver,spleen channel.Fourthly,reasonable adjustment of the dosage of Aconitum can achiebe the balance of toxicity and effect,combining the way of use,dosage form,main treatment,age,constitution and other factors,appropriate application is an effectibe way to ensure the safety of clinical medication.