| Purpose:Based on data mining technology,summarize the clinical treatment patterns of stable angina pectoris by mentors,and provide methods and basis for the treatment of stable angina pectoris;Exploring the clinical efficacy of different types of traditional Chinese medicine compound preparations in the treatment of stable angina pectoris with phlegm and blood stasis syndrome based on network meta-analysis,and ranking them to clarify the optimal intervention measures for the clinical treatment of stable angina pectoris with phlegm and blood stasis syndrome;Evaluate the effectiveness and safety of Danlou tablets in the treatment of stable angina pectoris with phlegm stasis syndrome through clinical randomized controlled trials,and provide evidence-based medical evidence for the optimization of traditional Chinese medicine treatment plans for stable angina pectoris;Based on compound network pharmacology,the effective ingredients of Danlou tablets and the core targets for treating coronary heart disease are predicted.The molecular mechanism of Danlou tablets in treating stable angina pectoris is is elaborated and verified through molecular docking,providing modern theoretical basis for clinical research of Danlou tablets.Material and method:1.Collect patients with stable angina pectoris treated by Professor Zhang Mingxue in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January2018 to December 2022,include the cases according to the inclusion and exclusion criteria,and extract relevant data to establish a database,and use Microsoft Office Excel 2022 to statistically analyze the general information,syndrome,single drug use frequency,sex and taste,frequency and frequency of menstruation,Analyze association rules and make visual charts through SPSS Modeler 18.0 software.Through SPSS Statistics 26.0 software,cluster analysis was performed and the analysis results were visualized to summarize the syndrome and treatment rules of tutor in treating stable angina pectoris.2.With "coronary heart disease","angina pectoris","stable angina pectoris","chest pain","phlegm and blood stasis" and "phlegm and blood stasis" as the subject words,the search was carried out by combining the subject words and free words,and the database was retrieved according to the Napier’s standard.-October 2022,CNKI,Wanfang,VIP,Pubmed,Cochrane Library,Embase,Web of Science,Eliminate the duplicate literature,and through reading the abstract and the full text,carry out the net meta-analysis of the final included literature to obtain the effective traditional Chinese medicine compound preparation for the treatment of stable angina pectoris with phlegm and blood stasis,and compare the curative effect differences between the drugs.3.Taking Liaoning University of Traditional Chinese Medicine as the leading unit,a multi-center practical randomized controlled study was conducted in 12 national clinical research bases of traditional Chinese medicine in Northeast,North China,Northwest,Central China,East China,South China and Southwest China.The subjects of the study were patients with stable angina pectoris with phlegm and blood stasis syndrome(a total of 304 cases).The control group(152 cases)was treated with conventional western medicine for stable angina pectoris,and the treatment group(152 cases)was treated with traditional Chinese medicine.Both groups received routine treatment of western medicine,and were divided into four subgroups according to the syndrome differentiation of traditional Chinese medicine: phlegm and blood stasis combined with qi deficiency,phlegm and blood stasis combined with qi stagnation,phlegm and blood stasis combined with poison accumulation.Based on the results of syndrome differentiation,the experimental group was treated with Danlou Tablet or Danlou Tablet Modified Intervention Therapy(phlegm and blood stasis combined with Qi deficiency+Codonopsis pilosula,Poria cocos,French Pinellia ternate;phlegm and blood stasis combined with Qi stagnation+Corydalis yanhusuo,Fructus Aurantii,French Pinellia ternate;phlegm and blood stasis combined with poison accumulation+rhubarb,polygonum cuspidatum,French Pinellia ternate).The central randomization system generates static block randomization sequence,and the subjects enter the corresponding group according to the assigned randomization sequence.The centralized random sequence allocation is adopted to achieve the principle of distribution concealment.The administrator of the random center does not participate in any link of the trial implementation and follow-up.The frequency of angina pectoris attack per week is the main efficacy evaluation index,and the secondary efficacy evaluation index includes the efficacy of western medicine(a.symptoms and signs:angina pectoris symptom score,SAQ scale;b.physical and chemical indicators: ECG efficacy evaluation,cardiac color ultrasound,exercise test,blood fat,blood sugar,blood coagulation,hemorheology,Hcy,hs-CRP or CRP),Chinese medicine syndrome(syndrome score,tongue picture,pulse picture)Long-term prognosis(end point,cardiovascular events).In order to evaluate the efficacy of on-site follow-up at the 0,4,12 and 24 weeks after the treatment,telephone follow-up was conducted at the 36 and 48 weeks after the treatment.The data of week 0(before treatment)and week 24(after treatment)were statistically analyzed,and the difference was considered statistically significant by P<0.05.4.Based on the network pharmacology method,search and screen the active ingredients of Danlou tablets through TCMSP platform;Prediction of potential action targets of active ingredients based on Swiss Target Predictiion database;Realize the network visualization of "drug-active component-action target" through Cytascape 3.8.0 software and screen the main active components of Danlou tablet in the treatment of coronary heart disease;Collect coronary heart disease gene targets through Drugbank and Genecards databases;Intersect the potential drug action target and disease target and import them into the String database for protein interaction network analysis(PPI)to further screen the core target of Danlou tablet in the treatment of coronary heart disease;The intersection target was imported into Metascape database for GO and KEGG enrichment analysis to analyze the biological function and possible action pathway of drug therapy disease target;Finally,the active substances and molecular mechanism of Danlou tablets in the treatment of coronary heart disease were screened and obtained.R 3.6.1 software is applied to realize the visualization of enrichment analysis results;Molecular docking verification is carried out through Auto Dock Tools 1.5.6software and molecular docking result visualization is realized through Py Mol software.Results:1.Data mining finally included 281 patients,including 100 men(35.6%)and 181 women(64.4%).The specific analysis results are as follows:(1)The distribution of syndrome elements: Qi deficiency(98.22%)has the highest frequency,followed by phlegm turbidity(89.32%),blood stasis(83.63),qi stagnation(64.77%),yin deficiency(40.21%),heat(38.08%)is less,and yang deficiency(2.69%)is the least.(2)Statistics of drug use: The 281 prescriptions included 178 Chinese herbal medicines,16 of which were used more than 100 times,including astragalus membranaceus,French Pinellia ternata,Trichosanthes kirilowii,Allium macrostemon,American ginseng,peach kernel,Bupleurum chinense,Poria cocos,keel,licorice,platycodon grandiflorum,Cimicifuga,red peony,Ophiopogon japonicus,roots of citronella,and tulip;The drug properties are mainly cold,warm and mild;The sweet,bitter and bitter drugs are used more frequently;The meridians of the lung,spleen,stomach and heart meridians are mostly used.(3)The association rule analysis of "American ginseng-astragalus-French pinellia-Gualou-Xiebai" and "American ginseng-astragalus-French pinellia-Gualou-Xiebai-Taoren-Chaihu" has the strongest correlation.It is concluded that the core prescription of the tutor for clinical treatment of stable angina pectoris is "American ginseng-astragalus-French pinellia-Gualou-Xiebai-Taoren-Chaihu"(4)Cluster analysis: drugs are classified into 8 categories,Category 1: American ginseng-Astragalus membranaceus-Pinellia ternate-Trichosanthes Gualou-Allium macrostemon;Category 2:Cimicifuga-Bupleurum chinense-Platycodon grandiflorum;Category 3: peach kernel-safflower-red peony;Category 4: Cyperus-tulip;Category 5: Ophiopogon japonicus-Schisandra chinensis;Category 6: keel-licorice;Class 7: Poria cocos;Class 8: white fescue root.2.A total of 44 articles were included in the reticular meta-analysis,with a total of 3650 subjects,including 18 traditional Chinese medicine compound preparations.The results of reticular meta-analysis showed that:(1)In terms of the total clinical effective rate,compared with the conventional treatment of western medicine,Danlou Tablet+conventional,Gualou Xiebai Banxia Decoction plus conventional,self-made Danqu Formula+conventional,Xuefu Zhuyu Decoction plus conventional treatment can significantly improve the total clinical effective rate of patients with stable angina pectoris with phlegm-stasis syndrome(P<0.05),and the top two in the SUBRA ranking are Danlou Tablet+conventional,Gualou Xiebai Banxia Decoction plus conventional treatment;(2)In terms of the efficacy of angina pectoris symptoms,compared with the conventional treatment of western medicine,Danlou Tablet+conventional treatment,Gualou Xiebai Banxia Decoction+conventional treatment,Xintongning Granule+conventional treatment,Erchen Decoction+conventional treatment,Kudish Sanqi Decoction+conventional treatment,Sijunzi Decoction+conventional treatment,Xiaoxianxiong Decoction+conventional treatment can significantly improve the efficacy of angina pectoris symptoms in patients with stable angina pectoris with phlegm and blood stasis syndrome(P<0.05),and the top two in the SUCRA ranking are Danlou Tablet+conventional treatment Gualou Xiebai Banxia Decoction plus conventional treatment;(3)In terms of electrocardiographic efficacy,compared with conventional treatment of western medicine,Gualou Xiebai Banxia Decoction plus conventional treatment can significantly improve the electrocardiographic efficacy of patients with stable angina pectoris with phlegm-stasis syndrome(P<0.05),and the top two in the SUBRA ranking are Gualou Xiebai Banxia Decoction plus conventional treatment and Danlou Tablets plus conventional treatment;(4)In terms of nitroglycerin withdrawal rate,compared with conventional western medicine treatment,Danlou Tablet+conventional,Gualou Xiebai Banxia Decoction plus conventional,Xiaoqianxiong Decoction plus conventional,Wendan Decoction plus conventional treatment can significantly improve the nitroglycerin withdrawal rate of patients with stable angina pectoris with phlegm and blood stasis syndrome(P<0.05),and the top two in the SUBRA ranking are Danlou Tablet+conventional,Gualou Xiebai Banxia Decoction plus conventional treatment;(5)In terms of hs-CRP,there was no significant difference between the intervention measures and conventional western medicine(P>0.05).The effect of Danlou Tablet+conventional western medicine treatment on reducing the level of hs-CRP was significantly better than that of Xuefu Zhuyu Decoction plus conventional treatment(P<0.05),and Danlou Tablet ranked first in the probability of SUCRA.3.This study ultimately included 300 participants in the FAS analysis set,including 151 in the traditional Chinese medicine treatment group and 149 in the conventional Western medicine treatment group;The PPS set consisted of 266 subjects,including 137 cases in the traditional Chinese medicine treatment group and 129 cases in the conventional Western medicine treatment group.The statistical analysis results were as follows:(1)Comparison of baseline data: Except for smoking,whether there are endocrine and metabolic diseases,fasting blood glucose,and angina symptom scores,the difference between the two groups was statistically significant(P<0.05),and all other baseline data comparisons between the groups were not statistically significant(P>0.05).The overall baseline balance between the two groups is good and comparable.(2)FAS set: 1)Main efficacy indicator: Weekly frequency of angina attacks: After receiving corresponding intervention treatment,the frequency of weekly angina attacks in both groups was significantly reduced(P<0.05).Compared to the conventional Western medicine treatment group,the traditional Chinese medicine differentiation group has a more significant therapeutic effect in reducing the frequency of weekly angina attacks(P<0.05).2)Secondary efficacy indicators:(1)Angina symptom score efficacy: Both groups after receiving corresponding intervention treatment can improve the total effective rate of angina symptom score in subjects with stable angina and phlegm stasis syndrome and its concurrent symptoms(P<0.05),and the combination of conventional Western medicine and Danlou tablets and their modified treatment is more significant in improving the total effective rate of angina symptoms compared to simple Western medicine treatment(P<0.05).(2)Effect of Traditional Chinese Medicine Syndrome Integration: Both groups receiving corresponding intervention treatment can improve the total effective rate of traditional Chinese medicine syndrome integration in stable angina pectoris patients with phlegm stasis syndrome and its concurrent symptoms(P<0.05),and the combination of conventional Western medicine and Danlou tablets and their modified treatment has a significant advantage in improving the total effective rate of traditional Chinese medicine syndrome integration in stable coronary heart disease patients with phlegm stasis syndrome and its concurrent symptoms(P<0.05)compared to conventional Western medicine treatment Evaluation of electrocardiogram efficacy: After 24 weeks of intervention treatment,the total effective rate of electrocardiogram efficacy evaluation in both groups showed an increasing trend.The traditional Chinese medicine differentiation group was significantly better than the conventional Western medicine group,indicating that Danlou tablets and their modified combination with conventional Western medicine treatment had a significantly better effect than conventional Western medicine treatment in improving the total effective rate of electrocardiogram efficacy evaluation(P<0.05)Seattle Angina Scale: Conventional Western medicine combined with Danlou tablets and their modified treatments can significantly improve the total score and various dimensions of the Seattle Angina Scale(P<0.05),and have significant advantages over conventional Western medicine treatment Summary of Health Status(SF-36): Conventional Western Medicine Combined with Danlou Tablets and Its Modified Treatment can significantly improve the total score and various dimensions of the Health Status Summary(P<0.05),and has significant advantages over conventional Western Medicine treatment.(6)Cardiac Doppler Ultrasound: The combination of conventional Western medicine and Danlou tablets and their modified treatments showed no significant changes in all aspects of cardiac ultrasound compared to baseline,and there was no significant difference between the two groups(P>0.05)Laboratory examination: a.Homocysteine(Hcy): Conventional Western medicine combined with Danlou tablets and their modified treatments can significantly reduce the homocysteine levels of patients with stable angina pectoris with phlegm stasis syndrome and its concurrent symptoms(P<0.05),which has certain advantages over simple Western medicine treatment.b.Four items of blood coagulation,blood lipids,blood glucose,hemorheology,C-reactive protein/hypersensitive C-reactive protein: after treatment,conventional western medicine combined with Danlou tablet and its modified treatment had no significant effect on improving blood glucose(P>0.05).There was no significant difference between the two groups in the four items of blood coagulation,blood lipids,hemorheology,C-reactive protein/high-sensitivity C-reactive protein(P>0.05).(3)PPS set: 1)Main efficacy indicator: Weekly frequency of angina attacks:After receiving corresponding intervention treatment,the frequency of weekly angina attacks in both groups was significantly reduced(P<0.05).Compared to the conventional Western medicine treatment group,the traditional Chinese medicine differentiation group has a more significant therapeutic effect in reducing the frequency of weekly angina attacks(P<0.05).2)Secondary efficacy indicators:(1)Angina symptom score efficacy: Both groups after receiving corresponding intervention treatment can improve the total effective rate of angina symptom score in subjects with stable angina and phlegm stasis syndrome and its concurrent symptoms(P<0.05),and the combination of conventional Western medicine and Danlou tablets and their modified treatment is more significant in improving the total effective rate of angina symptoms compared to simple Western medicine treatment(P<0.05).(2)Effect of Traditional Chinese Medicine Syndrome Integration: Both groups receiving corresponding intervention treatment can improve the total effective rate of traditional Chinese medicine syndrome integration in stable angina pectoris patients with phlegm stasis syndrome and its concurrent symptoms(P<0.05),and the combination of conventional Western medicine and Danlou tablets and their modified treatment has a significant advantage in improving the total effective rate of traditional Chinese medicine syndrome integration in stable coronary heart disease patients with phlegm stasis syndrome and its concurrent symptoms(P<0.05)compared to conventional Western medicine treatment Evaluation of electrocardiographic efficacy: After 24 weeks of intervention treatment,the total effective rate of electrocardiographic efficacy evaluation in both groups showed an increasing trend.The traditional Chinese medicine differentiation group was significantly better than the conventional Western medicine group,indicating that Danlou tablets and their modified combination with conventional Western medicine treatment had a significantly better effect than conventional Western medicine treatment in improving the total effective rate of electrocardiographic efficacy evaluation(P<0.05)Seattle Angina Scale: Conventional Western medicine combined with Danlou tablets and their modified treatments can significantly improve the total score and various dimensions of the Seattle Angina Scale(P<0.05),and have significant advantages over conventional Western medicine treatment Summary of Health Status(SF-36): The combination of conventional Western medicine and Danlou tablets and their flavored treatment can significantly improve the total score and various dimensions of the health status summary(P<0.05),and significantly outperform simple Western medicine treatment in improving the total score,physiological function,physiological function,physical pain,overall health,vitality,social function,emotional function,and changes in health status.(6)Cardiac Doppler Ultrasound: The combination of conventional Western medicine and Danlou tablets and their modified treatments showed no significant changes in all aspects of cardiac ultrasound compared to baseline,and there was no significant difference between the two groups(P>0.05)Laboratory examination: a.Coagulation four items: Conventional Western medicine combined with Danlou tablets and their modified treatment can significantly prolong the activated partial thromboplastin time(P<0.05)of patients with stable angina pectoris with phlegm stasis syndrome and its concurrent symptoms,which has advantages over conventional Western medicine treatment.b.Lipids: After 24 weeks of intervention treatment,the triglyceride levels in the traditional Chinese medicine differentiation group were significantly lower than those in the conventional Western medicine treatment group(P<0.05).c.Homocysteine(Hcy): The combination of conventional Western medicine and Danlou tablets and their modified treatments can significantly reduce the homocysteine levels in patients with stable angina pectoris with phlegm stasis syndrome and its concurrent symptoms(P<0.05),which has certain advantages over simple Western medicine treatment.d.Blood sugar,hemorheology,C-reactive protein/hypersensitive C-reactive protein: after treatment,conventional western medicine combined with Danlou tablet and its modified treatment had no significant effect on improving blood sugar(P>0.05).There was no significant difference in hemorheology,C-reactive protein/high-sensitivity C-reactive protein between the two groups(P>0.05).(4)Safety analysis: In the SS analysis set,there was no significant difference(P>0.05)in the incidence of adverse events,severity of adverse events,and incidence of serious adverse events between conventional Western medicine combined with Danlou tablets and their modified treatment compared to simple Western medicine treatment,and there was no significant difference(P>0.05)in safety indicators such as blood routine,liver and kidney function,and urine/stool routine compared to simple Western medicine treatment.(5)Long term follow-up: In the SS analysis set,there was no significant difference(P>0.05)between the two groups of subjects in terms of whether they had comorbidities,the type of comorbidities(there was a statistically significant difference in endocrine and metabolic system diseases(P<0.05),the incidence of endocrine and metabolic system diseases was higher in the conventional Western medicine treatment group,which was consistent with the baseline period),and the duration of comorbidities(P>0.05).There were no cases of blood vessel reconstruction,death,or readmission during the follow-up period.4.Network pharmacological research results:(1)The key active ingredients of Danlou tablet in the treatment of coronary heart disease: This study combined with the TCMSP database platform and the screening of the reported effective active ingredients of Danlou tablet in the treatment of coronary heart disease,a total of 165 potential active compounds were obtained,including 9 Trichosanthes kirilowii,11 Allium macrostemon,3 pueraria lobata,7 Chuanxiong,64 Salvia miltiorrhiza,28 paeonia rubra,10 Alisma orientalis,20 astragalus,18 Drynaria,and14 tulips.There are 344 potential drug targets and 145 targets with coronary heart disease genes.Through network topology analysis,quercetin,luteolin,kaempferol,naringin,alisol C,beta-sitosterol,isorhamnetin,alisol B acetate may be the key active components of Danlou tablets in the treatment of coronary heart disease.(2)The core target of Danlou Tablet in treating coronary heart disease: through the analysis of protein interaction network,eight core targets MAPK3,ALB,AKT1,VEGFA,TNF,MAPK1,IL6,EGF were selected,which may be the core target of Danlou Tablet in treating coronary heart disease.(3)GO enrichment analysis.The drug components of Danlou Tablet mainly participate in the active oxygen metabolism process of the body,the response to lipopolysaccharide,the response to bacterial molecules,the response to oxygen level,the oxidative stress response,the positive regulation of extracellular stimulation response,the positive regulation of cell migration,the positive regulation of blood circulation,the positive regulation of kinase activity,the positive regulation of cellular response to lipids,and the positive regulation of the activity of transferases Biological processes such as transmembrane receptor protein tyrosine kinase signal pathway play a therapeutic role in coronary heart disease.The drug components mainly act on membrane pits and platelets α Granular cavity,plasma membrane raft and other cell components.The molecular function of the drug components of Danlou tablet in the treatment of coronary heart disease may be related to the activity of transcription factors and nuclear receptors that directly regulate sequence-specific DNA binding.(4)KEGG pathway analysis:AGE-RAGE signaling pathway and IL-17 signaling pathway in have the highest enrichment and strong significance.(5)Molecular docking results: All receptor proteins and small molecular ligands are well docked,among which the top six binding free energies are:(1)TNF and alisol,b,23-acetate(-8.94 kcal · mol-1),(2)TNF and beta-sitosterol(-8.89kcal·mol-1),(3)AKT1 and alisol C(-8.71 kcal·mol-1),(4)AKT1 and quercetin(-8.13kcal·mol-1),(5)AKT1 and luteolin(-8.1 kcal·mol-1)(6)EGF and kaempferol(-8.1kcal·mol-1).Conclusion:1.Based on the results of data mining,the pathogenesis of stable angina pectoris is always based on the deficiency of the original and the actual.It is based on the deficiency of qi,with turbid phlegm,blood stasis,qi stagnation and fire(heat)as the standard.The disease is located in the heart and is closely related to the lung,liver and spleen.In the clinical treatment of stable angina pectoris,instructors often take the basic treatment of supplementing qi and activating blood circulation to dissipate phlegm,treat phlegm and blood stasis together,regulate qi and blood,and give consideration to both samples.The core prescription is American ginseng,astragalus,French pinellia,trichosanthes,allium macrostemon,peach kernel,and bupleurum chinense.If the patient is prone to qi deficiency or atmospheric depression at the time of clinical treatment,the core prescription and Shengshen Decoction shall be added or subtracted;For those who are inclined to yin deficiency,increase or decrease of Hesheng pulse drink;For those mainly with blood stasis,Hexuefu Zhuyu Decoction should be added or reduced;For patients with turbid phlegm,add poria cocos and other drugs for removing dampness and resolving phlegm;For those who are mainly qi stagnation,add herbs such as Cyperus and Curcuma to promote qi and blood circulation;For those with fire(heat)as the main ingredient,add the heat-clearing and blood-cooling drugs such as the root of white fescue.Based on the statistical analysis of the frequency of syndrome elements and the core prescription and main treatment of the tutor,it can be concluded that the main syndrome type of stable angina pectoris is the syndrome of phlegm and blood stasis.2.Based on the results of reticular meta-analysis,the addition of traditional Chinese medicine compound preparation on the basis of conventional western medicine can significantly improve the total clinical effective rate of patients with stable angina pectoris with phlegm-stasis syndrome,improve the symptoms of angina pectoris,improve the efficacy of electrocardiogram,and reduce the amount of nitroglycerin.Among them,Danlou Tablet+conventional treatment,Gualou Xiebai Banxia Decoction+conventional treatment have significant advantages over other intervention measures in improving the total clinical effective rate of patients with stable angina pectoris,the efficacy of angina pectoris symptoms,the efficacy of ECG,and the rate of nitroglycerin withdrawal and reduction,which may be the best intervention treatment method.In terms of reducing the level of hs-CRP,there is no significant difference between the intervention measures of traditional Chinese medicine and conventional western medicine.According to the SUCRA probability ranking,Danlou tablets+conventional treatment may be the best intervention measures to reduce the level of hs-CRP.At the same time,the therapeutic advantages of Gualou Xiebai Banxia Decoction plus conventional treatment in terms of clinical total effective rate,angina symptom efficacy,electrocardiogram efficacy,and nitroglycerin reduction rate further demonstrate the effectiveness of the core prescription "American ginseng Huangqi Fabanxia Gualou Xiebai Taoren Chaihu" in the clinical treatment of this disease,which is equivalent to the clinical efficacy of Danlou tablets.The prescription idea is the same,and the treatment principle is to activate phlegm.3.According to the statistical analysis results of clinical trials,the use of Danlou tablet and its modified treatment based on syndrome differentiation of traditional Chinese medicine can significantly reduce the frequency of angina pectoris attacks per week in patients with stable angina pectoris with phlegm and blood stasis syndrome and its concurrent symptoms,improve the efficacy of angina pectoris symptoms,the efficacy of TCM syndrome accumulation and the efficacy of electrocardiogram,extend the time of activating partial prothrombin,and reduce the level of triglyceride and homocysteine,The improvement of the score of the Seattle Angina Pectoris Scale and the short scale of health status has obvious advantages over the simple western medicine treatment,and the safety and long-term prognosis are good.It is worthy of further research and clinical application and promotion.In addition,this study adopts a combination of symptomatic intervention programs based on the main disease and main syndrome intervention programs,which fully reflects the traditional Chinese medicine characteristic dialectical thinking of "syndrome differentiation based on image and combination of disease and syndrome" and the traditional Chinese medicine characteristic clinical thinking of "method and image to the full extent,and corresponding formula and syndrome",highlighting the diagnosis and treatment advantages of traditional Chinese medicine syndrome differentiation and treatment characteristics,and also reveals the superiority and effectiveness of p RCT in clinical trials of traditional Chinese medicine,In the clinical trials of traditional Chinese medicine,the p RCT research method can strengthen the causal relationship between the intervention based on differentiation and treatment of traditional Chinese medicine and the determination of curative effect,so as to improve the clinical evidence of traditional Chinese medicine and improve the level of evidence.Through the design of multi-center practical randomized controlled clinical trial and the strict scientific research design in line with the evidence-based requirements,this study reveals the efficacy advantages of the method of activating blood circulation and resolving phlegm and the method of evidence-based Chinese medicine treatment,ensures the positivity and applicability of the evidence,and provides an example of methodological innovation and application for clinical research of Chinese medicine.It has identified the suitable population for the treatment of TCM according to symptoms,and the efficacy advantages of early intervention of coronary heart disease,providing high-quality evidence-based basis for optimizing the prevention and treatment of stable angina pectoris with TCM.4 According to the results of network pharmacology,the mechanism of Danlou Tablet in treating coronary heart disease may be that the active components of Danlou Tablet mainly regulate the expression of AGE-RAGE signal pathway and IL-17 signal pathway,thereby reducing NF-κ,The activation of B inhibits the expression and release of adhesion molecules,vascular endothelial growth factor(VEGF),inflammatory cytokines,etc.,thereby reducing oxidative stress and inflammatory reaction,delaying the process of coronary atherosclerosis,protecting vascular endothelial function,and playing a therapeutic role in coronary heart disease. |
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